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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
J Neurochem. 2004 Nov; 91(3):513-20.JN

Abstract

Accumulating evidence points to an important role of intraneuronal A beta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. In the present article, we review recent findings on intracellular monomeric and oligomeric beta-amyloid (A beta) generation and its pathological function in cell culture, transgenic AD mouse models and post mortem brain tissue of AD and Down syndrome patients, as well as its interaction with oxidative stress and its relevance in apoptotic cell death. Based on these results, a modified A beta hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD-typical neuron loss and plaque formation.

Authors+Show Affiliations

Saarland University, Department of Psychiatry, Division of Neurobiology, 66421 Homburg/Saar, Germany. oliver.wirths@uniklinik-saarland.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15485483

Citation

Wirths, Oliver, et al. "A Modified Beta-amyloid Hypothesis: Intraneuronal Accumulation of the Beta-amyloid Peptide--the First Step of a Fatal Cascade." Journal of Neurochemistry, vol. 91, no. 3, 2004, pp. 513-20.
Wirths O, Multhaup G, Bayer TA. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade. J Neurochem. 2004;91(3):513-20.
Wirths, O., Multhaup, G., & Bayer, T. A. (2004). A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade. Journal of Neurochemistry, 91(3), 513-20.
Wirths O, Multhaup G, Bayer TA. A Modified Beta-amyloid Hypothesis: Intraneuronal Accumulation of the Beta-amyloid Peptide--the First Step of a Fatal Cascade. J Neurochem. 2004;91(3):513-20. PubMed PMID: 15485483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade. AU - Wirths,Oliver, AU - Multhaup,Gerd, AU - Bayer,Thomas A, PY - 2004/10/16/pubmed PY - 2005/3/25/medline PY - 2004/10/16/entrez SP - 513 EP - 20 JF - Journal of neurochemistry JO - J. Neurochem. VL - 91 IS - 3 N2 - Accumulating evidence points to an important role of intraneuronal A beta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. In the present article, we review recent findings on intracellular monomeric and oligomeric beta-amyloid (A beta) generation and its pathological function in cell culture, transgenic AD mouse models and post mortem brain tissue of AD and Down syndrome patients, as well as its interaction with oxidative stress and its relevance in apoptotic cell death. Based on these results, a modified A beta hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD-typical neuron loss and plaque formation. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/15485483/A_modified_beta_amyloid_hypothesis:_intraneuronal_accumulation_of_the_beta_amyloid_peptide__the_first_step_of_a_fatal_cascade_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=2004&volume=91&issue=3&spage=513 DB - PRIME DP - Unbound Medicine ER -