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Comparison of the metabolic and antioxidant effects of diltiazem and vitamin E on streptozotocin-diabetic rats.
J Vet Med A Physiol Pathol Clin Med. 2004 Aug; 51(6):265-7.JV

Abstract

In this study, solitary and combined effects of vitamin E and the calcium-channel blocker diltiazem were investigated in streptozotocin (STZ)-induced diabetic rats. Thirty male Wistar albino rats, weighing approximately 200 g were used. Diabetes mellitus was induced by a single intravenous injection of STZ at a dose of 65 mg/kg body weight. Five experimental groups were established as STZ-diabetic, STZ-diabetic + vitamin E, STZ-diabetic + diltiazem and STZ-diabetic + vitamin E + diltiazem. Vitamin E was injected intraperitoneally three times a week at a dose of 500 mg/kg body weight. Diltiazem was given orally every day at a dose of 25 mg/kg body weight. At the end of the study (10 weeks) blood glucose levels of diabetic rats, which had received vitamin E and diltiazem, had significantly decreased when compared with untreated diabetic rats (P < 0.02). Similarly, HbA1c levels had significantly decreased in diabetic rats which had received vitamin E (P < 0.05), diltiazem (P < 0.01) and vitamin E + diltiazem (P < 0.02) when compared with untreated diabetic rats. Liver glutathione levels of diabetic rats, which had received vitamin E (P < 0.01) and vitamin E + diltiazem (P < 0.05) had significantly increased when compared with untreated diabetic rats. Liver lipid peroxide levels had significantly decreased in diabetic rats, which had received vitamin E (P < 0.001) and diltiazem (P < 0.01). With respect to their metabolic and antioxidant effects, vitamin E proved superior to diltiazem.

Authors+Show Affiliations

Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University, Avcilar 34851, Istanbul, Turkey. aakaymaz@istanbul.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15485559

Citation

Kaymaz, A Akdoğan, et al. "Comparison of the Metabolic and Antioxidant Effects of Diltiazem and Vitamin E On Streptozotocin-diabetic Rats." Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, vol. 51, no. 6, 2004, pp. 265-7.
Kaymaz AA, Telci A, Albeniz I, et al. Comparison of the metabolic and antioxidant effects of diltiazem and vitamin E on streptozotocin-diabetic rats. J Vet Med A Physiol Pathol Clin Med. 2004;51(6):265-7.
Kaymaz, A. A., Telci, A., Albeniz, I., Belce, A., & Altuğ, T. (2004). Comparison of the metabolic and antioxidant effects of diltiazem and vitamin E on streptozotocin-diabetic rats. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, 51(6), 265-7.
Kaymaz AA, et al. Comparison of the Metabolic and Antioxidant Effects of Diltiazem and Vitamin E On Streptozotocin-diabetic Rats. J Vet Med A Physiol Pathol Clin Med. 2004;51(6):265-7. PubMed PMID: 15485559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the metabolic and antioxidant effects of diltiazem and vitamin E on streptozotocin-diabetic rats. AU - Kaymaz,A Akdoğan, AU - Telci,A, AU - Albeniz,I, AU - Belce,A, AU - Altuğ,T, PY - 2004/10/16/pubmed PY - 2004/12/16/medline PY - 2004/10/16/entrez SP - 265 EP - 7 JF - Journal of veterinary medicine. A, Physiology, pathology, clinical medicine JO - J Vet Med A Physiol Pathol Clin Med VL - 51 IS - 6 N2 - In this study, solitary and combined effects of vitamin E and the calcium-channel blocker diltiazem were investigated in streptozotocin (STZ)-induced diabetic rats. Thirty male Wistar albino rats, weighing approximately 200 g were used. Diabetes mellitus was induced by a single intravenous injection of STZ at a dose of 65 mg/kg body weight. Five experimental groups were established as STZ-diabetic, STZ-diabetic + vitamin E, STZ-diabetic + diltiazem and STZ-diabetic + vitamin E + diltiazem. Vitamin E was injected intraperitoneally three times a week at a dose of 500 mg/kg body weight. Diltiazem was given orally every day at a dose of 25 mg/kg body weight. At the end of the study (10 weeks) blood glucose levels of diabetic rats, which had received vitamin E and diltiazem, had significantly decreased when compared with untreated diabetic rats (P < 0.02). Similarly, HbA1c levels had significantly decreased in diabetic rats which had received vitamin E (P < 0.05), diltiazem (P < 0.01) and vitamin E + diltiazem (P < 0.02) when compared with untreated diabetic rats. Liver glutathione levels of diabetic rats, which had received vitamin E (P < 0.01) and vitamin E + diltiazem (P < 0.05) had significantly increased when compared with untreated diabetic rats. Liver lipid peroxide levels had significantly decreased in diabetic rats, which had received vitamin E (P < 0.001) and diltiazem (P < 0.01). With respect to their metabolic and antioxidant effects, vitamin E proved superior to diltiazem. SN - 0931-184X UR - https://www.unboundmedicine.com/medline/citation/15485559/Comparison_of_the_metabolic_and_antioxidant_effects_of_diltiazem_and_vitamin_E_on_streptozotocin_diabetic_rats_ L2 - https://doi.org/10.1111/j.1439-0442.2004.00639.x DB - PRIME DP - Unbound Medicine ER -