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Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5.
Science. 2004 Oct 15; 306(5695):485-7.Sci

Abstract

Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.

Authors+Show Affiliations

Lederman MM
Department of Medicine, Case Western Reserve University, University Hospitals, 2061 Cornell Road, Cleveland, OH 44106, USA.
Veazey RS
No affiliation info available
Offord R
No affiliation info available
Mosier DE
No affiliation info available
Dufour J
No affiliation info available
Mefford M
No affiliation info available
Piatak M
No affiliation info available
Lifson JD
No affiliation info available
Salkowitz JR
No affiliation info available
Rodriguez B
No affiliation info available
Blauvelt A
No affiliation info available
Hartley O
No affiliation info available

MeSH

Administration, IntravaginalAnimalsAnti-HIV AgentsAnti-Infective Agents, LocalAntibodies, ViralCCR5 Receptor AntagonistsChemokine CCL5Dose-Response Relationship, DrugDrug Evaluation, PreclinicalFemaleHIV InfectionsHIV-1Macaca mulattaReceptors, CCR5Simian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVagina

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15486300

Citation

Lederman, Michael M., et al. "Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5." Science (New York, N.Y.), vol. 306, no. 5695, 2004, pp. 485-7.
Lederman MM, Veazey RS, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science. 2004;306(5695):485-7.
Lederman, M. M., Veazey, R. S., Offord, R., Mosier, D. E., Dufour, J., Mefford, M., Piatak, M., Lifson, J. D., Salkowitz, J. R., Rodriguez, B., Blauvelt, A., & Hartley, O. (2004). Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science (New York, N.Y.), 306(5695), 485-7.
Lederman MM, et al. Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5. Science. 2004 Oct 15;306(5695):485-7. PubMed PMID: 15486300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. AU - Lederman,Michael M, AU - Veazey,Ronald S, AU - Offord,Robin, AU - Mosier,Donald E, AU - Dufour,Jason, AU - Mefford,Megan, AU - Piatak,Michael,Jr AU - Lifson,Jeffrey D, AU - Salkowitz,Janelle R, AU - Rodriguez,Benigno, AU - Blauvelt,Andrew, AU - Hartley,Oliver, PY - 2004/10/16/pubmed PY - 2004/11/9/medline PY - 2004/10/16/entrez SP - 485 EP - 7 JF - Science (New York, N.Y.) JO - Science VL - 306 IS - 5695 N2 - Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/15486300/Prevention_of_vaginal_SHIV_transmission_in_rhesus_macaques_through_inhibition_of_CCR5_ DB - PRIME DP - Unbound Medicine ER -