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Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression.
J Affect Disord. 2004 Oct 15; 82(2):209-16.JA

Abstract

BACKGROUND

Previous findings in referred samples documented significant diagnostic specificity in patterns of transmission between parents with panic disorder (PD) and parents with major depression (MD) and their offspring. This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias.

METHODS

Parental PD/agoraphobia (AG) and parental MD were used to predict rates of offspring psychiatric disorders and functional outcomes using data from an opportunistic sample of parents (n = 991) and offspring (n = 734) ascertained from case-control family genetic studies of youth with and without attention-deficit hyperactivity disorder. Subjects were comprehensively assessed with structured diagnostic interview methodology to evaluate psychiatric disorders in parents and offspring.

RESULTS

Parental PD/AG increased the risk for anxiety disorders in offspring, independently of parental MD while parental MD increased the risk for mood and disruptive behavior disorders in offspring, independently of parental PD/AG. Parental psychopathology was also associated with functional impairment in offspring.

LIMITATIONS

The use of a sample ascertained by ADHD and control probands, and parent psychiatric diagnostic reports for children under 12.

CONCLUSIONS

These results extend to non-referred samples previous findings from referred samples documenting diagnostic specificity in the familial transmission of PD/AG and MD from parents to offspring, suggesting that these patterns of transmission are not due to referral bias. These results could inform and enhance community programs aimed at screening for and treating pediatric psychopathology.

Authors+Show Affiliations

Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St., Boston, MA 02114, USA. Jbiederman@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15488249

Citation

Biederman, Joseph, et al. "Does Referral Bias Impact Findings in High-risk Offspring for Anxiety Disorders? a Controlled Study of High-risk Children of Non-referred Parents With Panic Disorder/agoraphobia and Major Depression." Journal of Affective Disorders, vol. 82, no. 2, 2004, pp. 209-16.
Biederman J, Monuteaux MC, Faraone SV, et al. Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression. J Affect Disord. 2004;82(2):209-16.
Biederman, J., Monuteaux, M. C., Faraone, S. V., Hirshfeld-Becker, D. R., Henin, A., Gilbert, J., & Rosenbaum, J. F. (2004). Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression. Journal of Affective Disorders, 82(2), 209-16.
Biederman J, et al. Does Referral Bias Impact Findings in High-risk Offspring for Anxiety Disorders? a Controlled Study of High-risk Children of Non-referred Parents With Panic Disorder/agoraphobia and Major Depression. J Affect Disord. 2004 Oct 15;82(2):209-16. PubMed PMID: 15488249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression. AU - Biederman,Joseph, AU - Monuteaux,Michael C, AU - Faraone,Stephen V, AU - Hirshfeld-Becker,Dina R, AU - Henin,Aude, AU - Gilbert,Jennifer, AU - Rosenbaum,Jerrold F, PY - 2003/07/08/received PY - 2003/12/03/accepted PY - 2004/10/19/pubmed PY - 2005/2/24/medline PY - 2004/10/19/entrez SP - 209 EP - 16 JF - Journal of affective disorders JO - J Affect Disord VL - 82 IS - 2 N2 - BACKGROUND: Previous findings in referred samples documented significant diagnostic specificity in patterns of transmission between parents with panic disorder (PD) and parents with major depression (MD) and their offspring. This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias. METHODS: Parental PD/agoraphobia (AG) and parental MD were used to predict rates of offspring psychiatric disorders and functional outcomes using data from an opportunistic sample of parents (n = 991) and offspring (n = 734) ascertained from case-control family genetic studies of youth with and without attention-deficit hyperactivity disorder. Subjects were comprehensively assessed with structured diagnostic interview methodology to evaluate psychiatric disorders in parents and offspring. RESULTS: Parental PD/AG increased the risk for anxiety disorders in offspring, independently of parental MD while parental MD increased the risk for mood and disruptive behavior disorders in offspring, independently of parental PD/AG. Parental psychopathology was also associated with functional impairment in offspring. LIMITATIONS: The use of a sample ascertained by ADHD and control probands, and parent psychiatric diagnostic reports for children under 12. CONCLUSIONS: These results extend to non-referred samples previous findings from referred samples documenting diagnostic specificity in the familial transmission of PD/AG and MD from parents to offspring, suggesting that these patterns of transmission are not due to referral bias. These results could inform and enhance community programs aimed at screening for and treating pediatric psychopathology. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/15488249/Does_referral_bias_impact_findings_in_high_risk_offspring_for_anxiety_disorders_A_controlled_study_of_high_risk_children_of_non_referred_parents_with_panic_disorder/agoraphobia_and_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165032704000308 DB - PRIME DP - Unbound Medicine ER -