Tags

Type your tag names separated by a space and hit enter

Effect of reversible inactivation of the supramammillary nucleus on spatial learning and memory in rats.
Brain Res. 2004 Nov 12; 1026(2):267-74.BR

Abstract

Memory includes processes such as acquisition, consolidation and retrieval. Reference memory (RM) and working memory (WM) are two kinds of memory that can be assessed in rodents using spatial tasks, especially using the Morris water maze. The Morris water maze is particularly sensitive to hippocampal lesions. The supramammillary nucleus (SuM) has strong links with the hippocampus and septum. The role of the SuM on spatial learning is controversial. In the present study, involvement of SuM in the different steps of spatial RM and WM was investigated in the Morris water maze using reversible inactivation of SuM with lidocaine. Lidocaine (0.5 microl, 4%) was injected into the SuM through a guide cannula implanted above the SuM. The rats were trained on RM and WM versions of the Morris water maze. SuM was inactivated before training or immediately after training or before the probe trial of retrieval tests. Reversible inactivation of the SuM impaired consolidation of RM, and of consolidation and retrieval of WM. Therefore, it seems that activity of SuM neurons plays a role in spatial RM and WM learning and memory in the rat.

Authors+Show Affiliations

Department of Physiology and Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. siamakshahidi@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15488489

Citation

Shahidi, Siamak, et al. "Effect of Reversible Inactivation of the Supramammillary Nucleus On Spatial Learning and Memory in Rats." Brain Research, vol. 1026, no. 2, 2004, pp. 267-74.
Shahidi S, Motamedi F, Naghdi N. Effect of reversible inactivation of the supramammillary nucleus on spatial learning and memory in rats. Brain Res. 2004;1026(2):267-74.
Shahidi, S., Motamedi, F., & Naghdi, N. (2004). Effect of reversible inactivation of the supramammillary nucleus on spatial learning and memory in rats. Brain Research, 1026(2), 267-74.
Shahidi S, Motamedi F, Naghdi N. Effect of Reversible Inactivation of the Supramammillary Nucleus On Spatial Learning and Memory in Rats. Brain Res. 2004 Nov 12;1026(2):267-74. PubMed PMID: 15488489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of reversible inactivation of the supramammillary nucleus on spatial learning and memory in rats. AU - Shahidi,Siamak, AU - Motamedi,Fereshteh, AU - Naghdi,Nasser, PY - 2004/08/15/accepted PY - 2004/10/19/pubmed PY - 2005/2/3/medline PY - 2004/10/19/entrez SP - 267 EP - 74 JF - Brain research JO - Brain Res VL - 1026 IS - 2 N2 - Memory includes processes such as acquisition, consolidation and retrieval. Reference memory (RM) and working memory (WM) are two kinds of memory that can be assessed in rodents using spatial tasks, especially using the Morris water maze. The Morris water maze is particularly sensitive to hippocampal lesions. The supramammillary nucleus (SuM) has strong links with the hippocampus and septum. The role of the SuM on spatial learning is controversial. In the present study, involvement of SuM in the different steps of spatial RM and WM was investigated in the Morris water maze using reversible inactivation of SuM with lidocaine. Lidocaine (0.5 microl, 4%) was injected into the SuM through a guide cannula implanted above the SuM. The rats were trained on RM and WM versions of the Morris water maze. SuM was inactivated before training or immediately after training or before the probe trial of retrieval tests. Reversible inactivation of the SuM impaired consolidation of RM, and of consolidation and retrieval of WM. Therefore, it seems that activity of SuM neurons plays a role in spatial RM and WM learning and memory in the rat. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15488489/Effect_of_reversible_inactivation_of_the_supramammillary_nucleus_on_spatial_learning_and_memory_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(04)01353-8 DB - PRIME DP - Unbound Medicine ER -