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Opioid receptor subtype antagonists differentially alter GABA agonist-induced feeding elicited from either the nucleus accumbens shell or ventral tegmental area regions in rats.
Brain Res. 2004 Nov 12; 1026(2):284-94.BR

Abstract

Food intake is significantly increased by administration of either GABAA (e.g., muscimol) or GABAB (e.g., baclofen) agonists into either the shell region of the nucleus accumbens (NAC) or the ventral tegmental area (VTA); these responses are selectively blocked by pretreatment with corresponding GABAA and GABAB antagonists. Previous studies found that a single dose (5 microg) of the general opioid antagonist, naltrexone reduced feeding elicited by muscimol, but not baclofen in the NAC shell, and reduced feeding elicited by baclofen, but not muscimol in the VTA. The present study compared feeding responses elicited by either muscimol or baclofen in either the VTA and NAC shell following pretreatment with equimolar doses of selective mu (0.4, 4 microg), delta (0.4, 4 microg), or kappa (0.6, 6 microg) opioid receptor subtype antagonists. Muscimol (25 ng) and baclofen (200 microg) each significantly and equi-effectively increased food intake over 4 h following VTA or NAC shell microinjections. Muscimol-induced feeding elicited from the VTA was significantly enhanced by mu or delta antagonists, and was significantly reduced by kappa antagonists. Baclofen-induced feeding elicited from the VTA was significantly reduced by mu or kappa, but not delta antagonists. Muscimol-induced feeding elicited from the NAC was significantly reduced by either mu, kappa or delta antagonists. Baclofen-induced feeding elicited from the NAC was significantly reduced by kappa or delta, but not mu antagonists. These data indicate differential opioid receptor subtype antagonist-induced mediation of GABA receptor subtype agonist-induced feeding elicited from the VTA and NAC shell. This is consistent with previously demonstrated differential GABA receptor subtype antagonist-induced mediation of opioid-induced feeding elicited from these same sites. Thus, functional relationships exist for the elaborate anatomical and physiological interactions between these two neurochemical systems in the VTA and NAC shell.

Authors+Show Affiliations

Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15488491

Citation

Khaimova, Eleonora, et al. "Opioid Receptor Subtype Antagonists Differentially Alter GABA Agonist-induced Feeding Elicited From Either the Nucleus Accumbens Shell or Ventral Tegmental Area Regions in Rats." Brain Research, vol. 1026, no. 2, 2004, pp. 284-94.
Khaimova E, Kandov Y, Israel Y, et al. Opioid receptor subtype antagonists differentially alter GABA agonist-induced feeding elicited from either the nucleus accumbens shell or ventral tegmental area regions in rats. Brain Res. 2004;1026(2):284-94.
Khaimova, E., Kandov, Y., Israel, Y., Cataldo, G., Hadjimarkou, M. M., & Bodnar, R. J. (2004). Opioid receptor subtype antagonists differentially alter GABA agonist-induced feeding elicited from either the nucleus accumbens shell or ventral tegmental area regions in rats. Brain Research, 1026(2), 284-94.
Khaimova E, et al. Opioid Receptor Subtype Antagonists Differentially Alter GABA Agonist-induced Feeding Elicited From Either the Nucleus Accumbens Shell or Ventral Tegmental Area Regions in Rats. Brain Res. 2004 Nov 12;1026(2):284-94. PubMed PMID: 15488491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid receptor subtype antagonists differentially alter GABA agonist-induced feeding elicited from either the nucleus accumbens shell or ventral tegmental area regions in rats. AU - Khaimova,Eleonora, AU - Kandov,Yakov, AU - Israel,Yuriy, AU - Cataldo,Giuseppe, AU - Hadjimarkou,Maria M, AU - Bodnar,Richard J, PY - 2004/08/15/accepted PY - 2004/10/19/pubmed PY - 2005/2/3/medline PY - 2004/10/19/entrez SP - 284 EP - 94 JF - Brain research JO - Brain Res VL - 1026 IS - 2 N2 - Food intake is significantly increased by administration of either GABAA (e.g., muscimol) or GABAB (e.g., baclofen) agonists into either the shell region of the nucleus accumbens (NAC) or the ventral tegmental area (VTA); these responses are selectively blocked by pretreatment with corresponding GABAA and GABAB antagonists. Previous studies found that a single dose (5 microg) of the general opioid antagonist, naltrexone reduced feeding elicited by muscimol, but not baclofen in the NAC shell, and reduced feeding elicited by baclofen, but not muscimol in the VTA. The present study compared feeding responses elicited by either muscimol or baclofen in either the VTA and NAC shell following pretreatment with equimolar doses of selective mu (0.4, 4 microg), delta (0.4, 4 microg), or kappa (0.6, 6 microg) opioid receptor subtype antagonists. Muscimol (25 ng) and baclofen (200 microg) each significantly and equi-effectively increased food intake over 4 h following VTA or NAC shell microinjections. Muscimol-induced feeding elicited from the VTA was significantly enhanced by mu or delta antagonists, and was significantly reduced by kappa antagonists. Baclofen-induced feeding elicited from the VTA was significantly reduced by mu or kappa, but not delta antagonists. Muscimol-induced feeding elicited from the NAC was significantly reduced by either mu, kappa or delta antagonists. Baclofen-induced feeding elicited from the NAC was significantly reduced by kappa or delta, but not mu antagonists. These data indicate differential opioid receptor subtype antagonist-induced mediation of GABA receptor subtype agonist-induced feeding elicited from the VTA and NAC shell. This is consistent with previously demonstrated differential GABA receptor subtype antagonist-induced mediation of opioid-induced feeding elicited from these same sites. Thus, functional relationships exist for the elaborate anatomical and physiological interactions between these two neurochemical systems in the VTA and NAC shell. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15488491/Opioid_receptor_subtype_antagonists_differentially_alter_GABA_agonist_induced_feeding_elicited_from_either_the_nucleus_accumbens_shell_or_ventral_tegmental_area_regions_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(04)01355-1 DB - PRIME DP - Unbound Medicine ER -