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Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings.
Psychiatry Res. 2004 Sep 30; 128(2):117-22.PR

Abstract

Major depression is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast to cortisol, dehydroepiandrosterone-sulfate (DHEA-S) has been less extensively studied in depressed patients. This study examined salivary morning and evening levels of cortisol and DHEA-S in 13 medicated, unipolar, non-psychotic depressed patients and 13 healthy volunteers. Diurnal declines in cortisol and DHEA-S levels were found in both depressed and control groups. In patients compared with controls, DHEA-S was significantly elevated, in conjunction with normal cortisol levels. Based on DHEA-S at 22:00 h only, 77% of the subjects were correctly classified in a discriminant analysis as depressed or control. When simultaneously entered in a multiple regression analysis, DHEA-S (morning and evening) and cortisol (evening only) predicted symptom severity in depressed patients. These preliminary results suggest that DHEA-S may be a more sensitive indicator of depression and symptom severity than cortisol in medicated but still clinically depressed patients.

Authors+Show Affiliations

Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands. j.assies@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15488954

Citation

Assies, Johanna, et al. "Elevated Salivary Dehydroepiandrosterone-sulfate but Normal Cortisol Levels in Medicated Depressed Patients: Preliminary Findings." Psychiatry Research, vol. 128, no. 2, 2004, pp. 117-22.
Assies J, Visser I, Nicolson NA, et al. Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings. Psychiatry Res. 2004;128(2):117-22.
Assies, J., Visser, I., Nicolson, N. A., Eggelte, T. A., Wekking, E. M., Huyser, J., Lieverse, R., & Schene, A. H. (2004). Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings. Psychiatry Research, 128(2), 117-22.
Assies J, et al. Elevated Salivary Dehydroepiandrosterone-sulfate but Normal Cortisol Levels in Medicated Depressed Patients: Preliminary Findings. Psychiatry Res. 2004 Sep 30;128(2):117-22. PubMed PMID: 15488954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated salivary dehydroepiandrosterone-sulfate but normal cortisol levels in medicated depressed patients: preliminary findings. AU - Assies,Johanna, AU - Visser,Ieke, AU - Nicolson,Nancy A, AU - Eggelte,Teunis A, AU - Wekking,Elisabeth M, AU - Huyser,Jochanan, AU - Lieverse,Ritsaert, AU - Schene,Aart H, PY - 2003/06/20/received PY - 2004/04/14/revised PY - 2004/05/26/accepted PY - 2004/10/19/pubmed PY - 2005/2/17/medline PY - 2004/10/19/entrez SP - 117 EP - 22 JF - Psychiatry research JO - Psychiatry Res VL - 128 IS - 2 N2 - Major depression is often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast to cortisol, dehydroepiandrosterone-sulfate (DHEA-S) has been less extensively studied in depressed patients. This study examined salivary morning and evening levels of cortisol and DHEA-S in 13 medicated, unipolar, non-psychotic depressed patients and 13 healthy volunteers. Diurnal declines in cortisol and DHEA-S levels were found in both depressed and control groups. In patients compared with controls, DHEA-S was significantly elevated, in conjunction with normal cortisol levels. Based on DHEA-S at 22:00 h only, 77% of the subjects were correctly classified in a discriminant analysis as depressed or control. When simultaneously entered in a multiple regression analysis, DHEA-S (morning and evening) and cortisol (evening only) predicted symptom severity in depressed patients. These preliminary results suggest that DHEA-S may be a more sensitive indicator of depression and symptom severity than cortisol in medicated but still clinically depressed patients. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/15488954/Elevated_salivary_dehydroepiandrosterone_sulfate_but_normal_cortisol_levels_in_medicated_depressed_patients:_preliminary_findings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165178104001325 DB - PRIME DP - Unbound Medicine ER -