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Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china.
Nutr Cancer. 2004; 49(2):125-30.NC

Abstract

To investigate whether intake of soy and isoflavones has an inverse association with ovarian cancer risk, a case-control study was conducted in Hangzhou, China. Cases were 254 patients with histologically confirmed epithelial ovarian cancer. The 652 controls comprised 340 hospital visitors, 261 non-neoplastic hospital outpatients, and 51 women recruited from the community. Habitual dietary intakes including 9 soy foods were measured by face-to-face interview using a validated and reliable food-frequency questionnaire. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) accounting for age, demographic characteristics, hormonal factors, and total energy intake. Intake of soy and isoflavones was inversely related to the risk of ovarian cancer. Compared with the highest versus the lowest quartile intake, the ORs were 0.50 (95% CI = 0.31-0.82) for total soy foods and 0.51 (95% CI = 0.31-0.85) for isoflavones. Among subgroups of soy foods and isoflavones, the ORs for soybeans, bean curd, daidzein, genistein, and glycitein were 0.35 (95% CI = 0.22-0.58), 0.49 (95% CI = 0.29-0.81), 0.52 (95% CI = 0.31-0.87), 0.50 (95% CI = 0.30-0.84), and 0.59 (95% CI = 0.35-0.97), respectively.

Authors+Show Affiliations

School of Public Health, Curtin University of Technology, Perth, WA, Australia. minzhang@sph.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15489204

Citation

Zhang, Min, et al. "Soy and Isoflavone Intake Are Associated With Reduced Risk of Ovarian Cancer in Southeast China." Nutrition and Cancer, vol. 49, no. 2, 2004, pp. 125-30.
Zhang M, Xie X, Lee AH, et al. Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china. Nutr Cancer. 2004;49(2):125-30.
Zhang, M., Xie, X., Lee, A. H., & Binns, C. W. (2004). Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china. Nutrition and Cancer, 49(2), 125-30.
Zhang M, et al. Soy and Isoflavone Intake Are Associated With Reduced Risk of Ovarian Cancer in Southeast China. Nutr Cancer. 2004;49(2):125-30. PubMed PMID: 15489204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy and isoflavone intake are associated with reduced risk of ovarian cancer in southeast china. AU - Zhang,Min, AU - Xie,Xing, AU - Lee,Andy H, AU - Binns,Colin W, PY - 2004/10/19/pubmed PY - 2005/4/9/medline PY - 2004/10/19/entrez SP - 125 EP - 30 JF - Nutrition and cancer JO - Nutr Cancer VL - 49 IS - 2 N2 - To investigate whether intake of soy and isoflavones has an inverse association with ovarian cancer risk, a case-control study was conducted in Hangzhou, China. Cases were 254 patients with histologically confirmed epithelial ovarian cancer. The 652 controls comprised 340 hospital visitors, 261 non-neoplastic hospital outpatients, and 51 women recruited from the community. Habitual dietary intakes including 9 soy foods were measured by face-to-face interview using a validated and reliable food-frequency questionnaire. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) accounting for age, demographic characteristics, hormonal factors, and total energy intake. Intake of soy and isoflavones was inversely related to the risk of ovarian cancer. Compared with the highest versus the lowest quartile intake, the ORs were 0.50 (95% CI = 0.31-0.82) for total soy foods and 0.51 (95% CI = 0.31-0.85) for isoflavones. Among subgroups of soy foods and isoflavones, the ORs for soybeans, bean curd, daidzein, genistein, and glycitein were 0.35 (95% CI = 0.22-0.58), 0.49 (95% CI = 0.29-0.81), 0.52 (95% CI = 0.31-0.87), 0.50 (95% CI = 0.30-0.84), and 0.59 (95% CI = 0.35-0.97), respectively. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/15489204/Soy_and_isoflavone_intake_are_associated_with_reduced_risk_of_ovarian_cancer_in_southeast_china_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc4902_2 DB - PRIME DP - Unbound Medicine ER -