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Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin.
J Neurol Neurosurg Psychiatry. 2004 Nov; 75(11):1553-7.JN

Abstract

OBJECTIVES

To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen.

METHODS

A long term (more than five years) observational longitudinal follow up study assessing 21 patients who received intrathecal baclofen given by programmable pump. Patients had chronic disabling spasticity which did not respond to oral antispasmolytic agents. Clinical efficacy was assessed by the Ashworth scale and spasm score; disability by the expanded disability status scale (EDSS), ambulation index (AI), and incapacity status scale (ISS); and health related quality of life by the sickness impact profile (SIP) and the Hopkins symptom checklist (HSCL).

RESULTS

Compared with pretreatment values, there was a significant improvement in clinical efficacy (Ashworth scale and spasm score, p<0.05) but a small but significant worsening of disability (EDSS, AI, and ISS, p<0.05). Comparing pretreatment with 26 weeks after pump implantation, a worsening was observed in disability (EDSS and ISS, p<0.05) and perceived health status (SIP, psychosocial dimension, p<0.05).

CONCLUSIONS

Long term administration of intrathecal baclofen delivered by an implanted programmable pump resulted in improved clinical efficacy but not in improvement in disability or perceived health status.

Authors+Show Affiliations

Department of Rehabilitation, University Groningen, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

15489386

Citation

Zahavi, A, et al. "Long Term Effect (more Than Five Years) of Intrathecal Baclofen On Impairment, Disability, and Quality of Life in Patients With Severe Spasticity of Spinal Origin." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 75, no. 11, 2004, pp. 1553-7.
Zahavi A, Geertzen JH, Middel B, et al. Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin. J Neurol Neurosurg Psychiatry. 2004;75(11):1553-7.
Zahavi, A., Geertzen, J. H., Middel, B., Staal, M., & Rietman, J. S. (2004). Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin. Journal of Neurology, Neurosurgery, and Psychiatry, 75(11), 1553-7.
Zahavi A, et al. Long Term Effect (more Than Five Years) of Intrathecal Baclofen On Impairment, Disability, and Quality of Life in Patients With Severe Spasticity of Spinal Origin. J Neurol Neurosurg Psychiatry. 2004;75(11):1553-7. PubMed PMID: 15489386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin. AU - Zahavi,A, AU - Geertzen,J H B, AU - Middel,B, AU - Staal,M, AU - Rietman,J S, PY - 2004/10/19/pubmed PY - 2004/12/16/medline PY - 2004/10/19/entrez SP - 1553 EP - 7 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatry VL - 75 IS - 11 N2 - OBJECTIVES: To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen. METHODS: A long term (more than five years) observational longitudinal follow up study assessing 21 patients who received intrathecal baclofen given by programmable pump. Patients had chronic disabling spasticity which did not respond to oral antispasmolytic agents. Clinical efficacy was assessed by the Ashworth scale and spasm score; disability by the expanded disability status scale (EDSS), ambulation index (AI), and incapacity status scale (ISS); and health related quality of life by the sickness impact profile (SIP) and the Hopkins symptom checklist (HSCL). RESULTS: Compared with pretreatment values, there was a significant improvement in clinical efficacy (Ashworth scale and spasm score, p<0.05) but a small but significant worsening of disability (EDSS, AI, and ISS, p<0.05). Comparing pretreatment with 26 weeks after pump implantation, a worsening was observed in disability (EDSS and ISS, p<0.05) and perceived health status (SIP, psychosocial dimension, p<0.05). CONCLUSIONS: Long term administration of intrathecal baclofen delivered by an implanted programmable pump resulted in improved clinical efficacy but not in improvement in disability or perceived health status. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/15489386/Long_term_effect__more_than_five_years__of_intrathecal_baclofen_on_impairment_disability_and_quality_of_life_in_patients_with_severe_spasticity_of_spinal_origin_ L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&amp;pmid=15489386 DB - PRIME DP - Unbound Medicine ER -