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[The distribution and clinical significance of IgG subclasses of anti-glomerular basement membrane antibodies].
Beijing Da Xue Xue Bao Yi Xue Ban. 2004 Oct; 36(5):501-4.BD

Abstract

OBJECTIVE

It was reported that major subclasses of anti-glomerular basement membrane (GBM) antibody were IgG1 and IgG4. The IgG1 subclass was mainly found in male patients and IgG4 subclass in female patients with anti-GBM disease. This study investigates the distribution of anti-GBM IgG subclasses and their association with clinical characteristics.

METHODS

Sera from 50 patients diagnosed as anti-GBM disease during 1991-2003 were collected. The anti-GBM antibodies with IgG1, IgG2, IgG3, and IgG4 subclasses were detected with purified bovine alpha (IV) NC1 as solid phase ligand in ELISA. The association with clinical manifestations was further investigated.

RESULTS

The positive rates of IgG anti-GBM subclasses were IgG1 94%, IgG2 56%, IgG3 12%, IgG4 88%, respectively. IgG1 and IgG4 were the main subclasses in anti-GBM IgG subclasses (P<0.01). The positive rates of the four subclasses had no significant difference between male and female, whereas the average positive percentage of IgG4 anti-GBM antibody was much higher in males than that in females (P<0.01). The average ages of patients with each subclass had no difference. The distribution of anti-GBM subclasses had no association with antineutrophil cytoplasmic antibody (ANCA), hematuria, proteinuria,or hemoptysis. The average positive percentage of IgG1 in patients with serum creatinine over 600 micromol/L was significantly higher than that in patients with serum creatinine less than 600 micromol/L (P<0.05), which suggested IgG1 might play an important role in the evolution and development of the disease. In the four patients with mild clinical presentations, three had IgG4 subclass, and only one patient who retained normal renal function in the follow-up exhibited pure IgG4 subclass. This suggested that IgG4 might not be inclined to cause severe damage. The average positive percentage of IgG4 subclass was higher in smoking patients than that in non-smoking patients (P<0.01).

CONCLUSION

There is a restrictive distribution among the subclasses of anti-GBM antibody, in which IgG1 and IgG4 are the main subclasses. The distribution of anti-GBM IgG subclasses was not associated with gender.

Authors+Show Affiliations

Department of Renal Division, Peking University First Hospital,Peking University Institute of Nephrology, Beijing 100034, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15489931

Citation

Yan, Yu, et al. "[The Distribution and Clinical Significance of IgG Subclasses of Anti-glomerular Basement Membrane Antibodies]." Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, vol. 36, no. 5, 2004, pp. 501-4.
Yan Y, Cui Z, Zhao MH. [The distribution and clinical significance of IgG subclasses of anti-glomerular basement membrane antibodies]. Beijing Da Xue Xue Bao. 2004;36(5):501-4.
Yan, Y., Cui, Z., & Zhao, M. H. (2004). [The distribution and clinical significance of IgG subclasses of anti-glomerular basement membrane antibodies]. Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, 36(5), 501-4.
Yan Y, Cui Z, Zhao MH. [The Distribution and Clinical Significance of IgG Subclasses of Anti-glomerular Basement Membrane Antibodies]. Beijing Da Xue Xue Bao. 2004;36(5):501-4. PubMed PMID: 15489931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The distribution and clinical significance of IgG subclasses of anti-glomerular basement membrane antibodies]. AU - Yan,Yu, AU - Cui,Zhao, AU - Zhao,Ming-hui, PY - 2004/10/19/pubmed PY - 2008/5/28/medline PY - 2004/10/19/entrez SP - 501 EP - 4 JF - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JO - Beijing Da Xue Xue Bao VL - 36 IS - 5 N2 - OBJECTIVE: It was reported that major subclasses of anti-glomerular basement membrane (GBM) antibody were IgG1 and IgG4. The IgG1 subclass was mainly found in male patients and IgG4 subclass in female patients with anti-GBM disease. This study investigates the distribution of anti-GBM IgG subclasses and their association with clinical characteristics. METHODS: Sera from 50 patients diagnosed as anti-GBM disease during 1991-2003 were collected. The anti-GBM antibodies with IgG1, IgG2, IgG3, and IgG4 subclasses were detected with purified bovine alpha (IV) NC1 as solid phase ligand in ELISA. The association with clinical manifestations was further investigated. RESULTS: The positive rates of IgG anti-GBM subclasses were IgG1 94%, IgG2 56%, IgG3 12%, IgG4 88%, respectively. IgG1 and IgG4 were the main subclasses in anti-GBM IgG subclasses (P<0.01). The positive rates of the four subclasses had no significant difference between male and female, whereas the average positive percentage of IgG4 anti-GBM antibody was much higher in males than that in females (P<0.01). The average ages of patients with each subclass had no difference. The distribution of anti-GBM subclasses had no association with antineutrophil cytoplasmic antibody (ANCA), hematuria, proteinuria,or hemoptysis. The average positive percentage of IgG1 in patients with serum creatinine over 600 micromol/L was significantly higher than that in patients with serum creatinine less than 600 micromol/L (P<0.05), which suggested IgG1 might play an important role in the evolution and development of the disease. In the four patients with mild clinical presentations, three had IgG4 subclass, and only one patient who retained normal renal function in the follow-up exhibited pure IgG4 subclass. This suggested that IgG4 might not be inclined to cause severe damage. The average positive percentage of IgG4 subclass was higher in smoking patients than that in non-smoking patients (P<0.01). CONCLUSION: There is a restrictive distribution among the subclasses of anti-GBM antibody, in which IgG1 and IgG4 are the main subclasses. The distribution of anti-GBM IgG subclasses was not associated with gender. SN - 1671-167X UR - https://www.unboundmedicine.com/medline/citation/15489931/[The_distribution_and_clinical_significance_of_IgG_subclasses_of_anti_glomerular_basement_membrane_antibodies]_ L2 - http://xuebao.bjmu.edu.cn/EN/Y2004/V36/I5/501 DB - PRIME DP - Unbound Medicine ER -