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Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa.
Planta Med. 2004 Oct; 70(10):904-8.PM

Abstract

The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively. Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data.

Authors+Show Affiliations

Adams M
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-Universität Graz, Austria.
Kunert O
No affiliation info available
Haslinger E
No affiliation info available
Bauer R
No affiliation info available

MeSH

EvodiaFruitGranulocytesHumansInhibitory Concentration 50LeukotrienesPhytotherapyPlant ExtractsQuinolones

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15490316

Citation

Adams, Michael, et al. "Inhibition of Leukotriene Biosynthesis By Quinolone Alkaloids From the Fruits of Evodia Rutaecarpa." Planta Medica, vol. 70, no. 10, 2004, pp. 904-8.
Adams M, Kunert O, Haslinger E, et al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004;70(10):904-8.
Adams, M., Kunert, O., Haslinger, E., & Bauer, R. (2004). Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Medica, 70(10), 904-8.
Adams M, et al. Inhibition of Leukotriene Biosynthesis By Quinolone Alkaloids From the Fruits of Evodia Rutaecarpa. Planta Med. 2004;70(10):904-8. PubMed PMID: 15490316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. AU - Adams,Michael, AU - Kunert,Olaf, AU - Haslinger,Ernst, AU - Bauer,Rudolf, PY - 2004/10/19/pubmed PY - 2004/12/16/medline PY - 2004/10/19/entrez SP - 904 EP - 8 JF - Planta medica JO - Planta Med VL - 70 IS - 10 N2 - The n-hexane extract of the fruits of Evodia rutaecarpa showed a considerable inhibiting effect on leukotriene biosynthesis in human granulocytes. Bioassay-guided fractionation of the extract led to the isolation of the 5 quinolone alkaloids: 1-methyl-2-nonyl-4(1H)-quinolinone, 1-methyl-2-(6Z)-6-undecenyl-4(1H)-quinolinone, 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl-4(1H)-quinolinone, evocarpine and 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl-4(1H)-quinolinone. The compounds exhibited inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1, 10.0, 10.1, 14,6 and 12.3 microM, respectively. Structure elucidation of the compounds was achieved by 1D and 2D NMR experiments and comparison of spectral data with literature data. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/15490316/Inhibition_of_leukotriene_biosynthesis_by_quinolone_alkaloids_from_the_fruits_of_Evodia_rutaecarpa_ DB - PRIME DP - Unbound Medicine ER -