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Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry.
Electrophoresis. 2004 Oct; 25(20):3441-9.E

Abstract

We describe an analytical method involving solid-phase extraction (SPE) and capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) for determining some pharmaceutical compounds - naproxen, clofibric acid and bezafibrate - in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous-organic solvent and CZE-ESI-MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from off-line SPE-CZE-MS and was validated with surface water. The detection limits were 100 ng.L(-1) for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid-liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits.

Authors+Show Affiliations

Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15490451

Citation

Macià, Alba, et al. "Determination of some Acidic Drugs in Surface and Sewage Treatment Plant Waters By Capillary Electrophoresis-electrospray Ionization-mass Spectrometry." Electrophoresis, vol. 25, no. 20, 2004, pp. 3441-9.
Macià A, Borrull F, Calull M, et al. Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry. Electrophoresis. 2004;25(20):3441-9.
Macià, A., Borrull, F., Calull, M., & Aguilar, C. (2004). Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry. Electrophoresis, 25(20), 3441-9.
Macià A, et al. Determination of some Acidic Drugs in Surface and Sewage Treatment Plant Waters By Capillary Electrophoresis-electrospray Ionization-mass Spectrometry. Electrophoresis. 2004;25(20):3441-9. PubMed PMID: 15490451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry. AU - Macià,Alba, AU - Borrull,Francesc, AU - Calull,Marta, AU - Aguilar,Carme, PY - 2004/10/19/pubmed PY - 2005/4/19/medline PY - 2004/10/19/entrez SP - 3441 EP - 9 JF - Electrophoresis JO - Electrophoresis VL - 25 IS - 20 N2 - We describe an analytical method involving solid-phase extraction (SPE) and capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) for determining some pharmaceutical compounds - naproxen, clofibric acid and bezafibrate - in real water samples. The electrospray parameters were optimized to maximize sensitivity. When a mixed aqueous-organic solvent and CZE-ESI-MS were used to analyze these drugs in water samples, the capillary was coated with hexadimethrin bromide (HDB) to permanently reverse the EOF. The method was developed from off-line SPE-CZE-MS and was validated with surface water. The detection limits were 100 ng.L(-1) for all analytes. The method was applied to analyze water samples from the influent and effluent of a sewage treatment plant. A liquid-liquid extraction step was required before SPE, and the compounds studied were found, some of them between detection and quantification limits. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/15490451/Determination_of_some_acidic_drugs_in_surface_and_sewage_treatment_plant_waters_by_capillary_electrophoresis_electrospray_ionization_mass_spectrometry_ L2 - https://doi.org/10.1002/elps.200406067 DB - PRIME DP - Unbound Medicine ER -