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Alcohol and the risk of prostate cancer and benign prostatic hyperplasia.

Abstract

OBJECTIVES

To examine the association between alcohol and the risk of prostate cancer/benign prostatic hyperplasia (BPH) in a population with a wide range of alcohol consumption, using a hospital-based, case-control study. Data from several epidemiologic studies have allowed us to exclude a strong association between alcohol drinking and prostate cancer risk. However, limited information is available for BPH. Also, it is unclear whether various types of alcoholic beverages may have a different impact on risk.

METHODS

We conducted this hospital-based case-control study in Italy between 1991 and 2002. A total of 2663 men younger than 75 years had incident, histologically confirmed prostate carcinoma (1294 cases) or symptomatic obstructive BPH (1369 cases) (maximal flow rate less than 15 mL/s) refractory to medical treatment. A total of 1451 patients younger than 75 years were used as controls. Odds ratios and corresponding 95% confidence intervals were estimated using unconditional multiple logistic regression models including terms for age, center, education, body mass index, physical activity, and family history of prostate cancer.

RESULTS

Alcohol consumption showed no consistent association with prostate cancer risk, but a statistically significant inverse trend in risk for BPH. Compared with abstainers, the odds ratio was 0.88 for fewer than three drinks, 0.71 for three to four drinks, 0.79 for five to six drinks, and 0.65 for seven or more drinks per day. The patterns of risk were similar with reference to different alcoholic beverages. The inverse relation between elevated alcohol consumption and BPH was apparently stronger in subjects with a lower body mass index.

CONCLUSIONS

Alcohol drinking is unrelated to prostate cancer risk. The inverse relationship with BPH may be related to the hormonal correlates (ie, lower androgen levels) of heavy alcohol drinkers.

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  • Authors+Show Affiliations

    ,

    Servizio di Epidemiologia, Istituto Tumori Fondazione Pascale, Naples, Italy.

    , , , , , , ,

    Source

    Urology 64:4 2004 Oct pg 717-22

    MeSH

    Adenocarcinoma
    Aged
    Alcohol Drinking
    Alcoholic Beverages
    Androgens
    Beer
    Body Mass Index
    Case-Control Studies
    Educational Status
    Humans
    Italy
    Male
    Middle Aged
    Motor Activity
    Prostatic Hyperplasia
    Prostatic Neoplasms
    Risk
    Risk Factors
    Wine

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    15491708

    Citation

    Crispo, Anna, et al. "Alcohol and the Risk of Prostate Cancer and Benign Prostatic Hyperplasia." Urology, vol. 64, no. 4, 2004, pp. 717-22.
    Crispo A, Talamini R, Gallus S, et al. Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. Urology. 2004;64(4):717-22.
    Crispo, A., Talamini, R., Gallus, S., Negri, E., Gallo, A., Bosetti, C., ... Montella, M. (2004). Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. Urology, 64(4), pp. 717-22.
    Crispo A, et al. Alcohol and the Risk of Prostate Cancer and Benign Prostatic Hyperplasia. Urology. 2004;64(4):717-22. PubMed PMID: 15491708.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. AU - Crispo,Anna, AU - Talamini,Renato, AU - Gallus,Silvano, AU - Negri,Eva, AU - Gallo,Antonio, AU - Bosetti,Cristina, AU - La Vecchia,Carlo, AU - Dal Maso,Luigino, AU - Montella,Maurizio, PY - 2004/03/01/received PY - 2004/05/04/accepted PY - 2004/10/20/pubmed PY - 2005/8/13/medline PY - 2004/10/20/entrez SP - 717 EP - 22 JF - Urology JO - Urology VL - 64 IS - 4 N2 - OBJECTIVES: To examine the association between alcohol and the risk of prostate cancer/benign prostatic hyperplasia (BPH) in a population with a wide range of alcohol consumption, using a hospital-based, case-control study. Data from several epidemiologic studies have allowed us to exclude a strong association between alcohol drinking and prostate cancer risk. However, limited information is available for BPH. Also, it is unclear whether various types of alcoholic beverages may have a different impact on risk. METHODS: We conducted this hospital-based case-control study in Italy between 1991 and 2002. A total of 2663 men younger than 75 years had incident, histologically confirmed prostate carcinoma (1294 cases) or symptomatic obstructive BPH (1369 cases) (maximal flow rate less than 15 mL/s) refractory to medical treatment. A total of 1451 patients younger than 75 years were used as controls. Odds ratios and corresponding 95% confidence intervals were estimated using unconditional multiple logistic regression models including terms for age, center, education, body mass index, physical activity, and family history of prostate cancer. RESULTS: Alcohol consumption showed no consistent association with prostate cancer risk, but a statistically significant inverse trend in risk for BPH. Compared with abstainers, the odds ratio was 0.88 for fewer than three drinks, 0.71 for three to four drinks, 0.79 for five to six drinks, and 0.65 for seven or more drinks per day. The patterns of risk were similar with reference to different alcoholic beverages. The inverse relation between elevated alcohol consumption and BPH was apparently stronger in subjects with a lower body mass index. CONCLUSIONS: Alcohol drinking is unrelated to prostate cancer risk. The inverse relationship with BPH may be related to the hormonal correlates (ie, lower androgen levels) of heavy alcohol drinkers. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15491708/Alcohol_and_the_risk_of_prostate_cancer_and_benign_prostatic_hyperplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(04)00575-8 DB - PRIME DP - Unbound Medicine ER -