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Alcohol and the risk of prostate cancer and benign prostatic hyperplasia.
Urology 2004; 64(4):717-22U

Abstract

OBJECTIVES

To examine the association between alcohol and the risk of prostate cancer/benign prostatic hyperplasia (BPH) in a population with a wide range of alcohol consumption, using a hospital-based, case-control study. Data from several epidemiologic studies have allowed us to exclude a strong association between alcohol drinking and prostate cancer risk. However, limited information is available for BPH. Also, it is unclear whether various types of alcoholic beverages may have a different impact on risk.

METHODS

We conducted this hospital-based case-control study in Italy between 1991 and 2002. A total of 2663 men younger than 75 years had incident, histologically confirmed prostate carcinoma (1294 cases) or symptomatic obstructive BPH (1369 cases) (maximal flow rate less than 15 mL/s) refractory to medical treatment. A total of 1451 patients younger than 75 years were used as controls. Odds ratios and corresponding 95% confidence intervals were estimated using unconditional multiple logistic regression models including terms for age, center, education, body mass index, physical activity, and family history of prostate cancer.

RESULTS

Alcohol consumption showed no consistent association with prostate cancer risk, but a statistically significant inverse trend in risk for BPH. Compared with abstainers, the odds ratio was 0.88 for fewer than three drinks, 0.71 for three to four drinks, 0.79 for five to six drinks, and 0.65 for seven or more drinks per day. The patterns of risk were similar with reference to different alcoholic beverages. The inverse relation between elevated alcohol consumption and BPH was apparently stronger in subjects with a lower body mass index.

CONCLUSIONS

Alcohol drinking is unrelated to prostate cancer risk. The inverse relationship with BPH may be related to the hormonal correlates (ie, lower androgen levels) of heavy alcohol drinkers.

Authors+Show Affiliations

Servizio di Epidemiologia, Istituto Tumori Fondazione Pascale, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

15491708

Citation

Crispo, Anna, et al. "Alcohol and the Risk of Prostate Cancer and Benign Prostatic Hyperplasia." Urology, vol. 64, no. 4, 2004, pp. 717-22.
Crispo A, Talamini R, Gallus S, et al. Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. Urology. 2004;64(4):717-22.
Crispo, A., Talamini, R., Gallus, S., Negri, E., Gallo, A., Bosetti, C., ... Montella, M. (2004). Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. Urology, 64(4), pp. 717-22.
Crispo A, et al. Alcohol and the Risk of Prostate Cancer and Benign Prostatic Hyperplasia. Urology. 2004;64(4):717-22. PubMed PMID: 15491708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and the risk of prostate cancer and benign prostatic hyperplasia. AU - Crispo,Anna, AU - Talamini,Renato, AU - Gallus,Silvano, AU - Negri,Eva, AU - Gallo,Antonio, AU - Bosetti,Cristina, AU - La Vecchia,Carlo, AU - Dal Maso,Luigino, AU - Montella,Maurizio, PY - 2004/03/01/received PY - 2004/05/04/accepted PY - 2004/10/20/pubmed PY - 2005/8/13/medline PY - 2004/10/20/entrez SP - 717 EP - 22 JF - Urology JO - Urology VL - 64 IS - 4 N2 - OBJECTIVES: To examine the association between alcohol and the risk of prostate cancer/benign prostatic hyperplasia (BPH) in a population with a wide range of alcohol consumption, using a hospital-based, case-control study. Data from several epidemiologic studies have allowed us to exclude a strong association between alcohol drinking and prostate cancer risk. However, limited information is available for BPH. Also, it is unclear whether various types of alcoholic beverages may have a different impact on risk. METHODS: We conducted this hospital-based case-control study in Italy between 1991 and 2002. A total of 2663 men younger than 75 years had incident, histologically confirmed prostate carcinoma (1294 cases) or symptomatic obstructive BPH (1369 cases) (maximal flow rate less than 15 mL/s) refractory to medical treatment. A total of 1451 patients younger than 75 years were used as controls. Odds ratios and corresponding 95% confidence intervals were estimated using unconditional multiple logistic regression models including terms for age, center, education, body mass index, physical activity, and family history of prostate cancer. RESULTS: Alcohol consumption showed no consistent association with prostate cancer risk, but a statistically significant inverse trend in risk for BPH. Compared with abstainers, the odds ratio was 0.88 for fewer than three drinks, 0.71 for three to four drinks, 0.79 for five to six drinks, and 0.65 for seven or more drinks per day. The patterns of risk were similar with reference to different alcoholic beverages. The inverse relation between elevated alcohol consumption and BPH was apparently stronger in subjects with a lower body mass index. CONCLUSIONS: Alcohol drinking is unrelated to prostate cancer risk. The inverse relationship with BPH may be related to the hormonal correlates (ie, lower androgen levels) of heavy alcohol drinkers. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15491708/Alcohol_and_the_risk_of_prostate_cancer_and_benign_prostatic_hyperplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(04)00575-8 DB - PRIME DP - Unbound Medicine ER -