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Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.
Cancer Res 2004; 64(20):7634-9CR

Abstract

Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously. An MPO G463A polymorphism exists in the promoter region, with the variant A allele conferring lower transcription activity than the common G allele. Because oxidative stress may play a role in breast carcinogenesis, we evaluated MPO genotypes in relation to breast cancer risk among 1,011 cases and 1,067 controls from the Long Island Breast Cancer Study Project (1996-1997). We also assessed the potential modifying effects of dietary antioxidants and hormonally related risk factors on these relationships. Women over 20 years with incident breast cancer who were residents of Nassau and Suffolk Counties, NY, were identified as potential cases. Population-based controls were frequency matched by 5-year age groups. Genotyping was performed with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) technology, and suspected breast cancer risk factors and usual dietary intake were assessed during an in-person interview. Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Having at least one A allele was associated with an overall 13% reduction in breast cancer risk. When consumption of fruits and vegetables and specific dietary antioxidants were dichotomized at the median, inverse associations with either GA or AA genotypes were most pronounced among women who consumed higher amounts of total fruits and vegetables (odds ratio, 0.75; 95% confidence interval, 0.58-0.97); this association was not noted among the low-consumption group (P for interaction = 0.04). Relationships were strongest among premenopausal women. Results from this first study of MPO genotypes and breast cancer risk indicate that MPO variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of breast cancer risk.

Authors+Show Affiliations

Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA. ja98@cornell.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15492293

Citation

Ahn, Jiyoung, et al. "Myeloperoxidase Genotype, Fruit and Vegetable Consumption, and Breast Cancer Risk." Cancer Research, vol. 64, no. 20, 2004, pp. 7634-9.
Ahn J, Gammon MD, Santella RM, et al. Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk. Cancer Res. 2004;64(20):7634-9.
Ahn, J., Gammon, M. D., Santella, R. M., Gaudet, M. M., Britton, J. A., Teitelbaum, S. L., ... Ambrosone, C. B. (2004). Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk. Cancer Research, 64(20), pp. 7634-9.
Ahn J, et al. Myeloperoxidase Genotype, Fruit and Vegetable Consumption, and Breast Cancer Risk. Cancer Res. 2004 Oct 15;64(20):7634-9. PubMed PMID: 15492293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk. AU - Ahn,Jiyoung, AU - Gammon,Marilie D, AU - Santella,Regina M, AU - Gaudet,Mia M, AU - Britton,Julie A, AU - Teitelbaum,Susan L, AU - Terry,Mary Beth, AU - Neugut,Alfred I, AU - Josephy,P David, AU - Ambrosone,Christine B, PY - 2004/10/20/pubmed PY - 2004/12/16/medline PY - 2004/10/20/entrez SP - 7634 EP - 9 JF - Cancer research JO - Cancer Res. VL - 64 IS - 20 N2 - Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously. An MPO G463A polymorphism exists in the promoter region, with the variant A allele conferring lower transcription activity than the common G allele. Because oxidative stress may play a role in breast carcinogenesis, we evaluated MPO genotypes in relation to breast cancer risk among 1,011 cases and 1,067 controls from the Long Island Breast Cancer Study Project (1996-1997). We also assessed the potential modifying effects of dietary antioxidants and hormonally related risk factors on these relationships. Women over 20 years with incident breast cancer who were residents of Nassau and Suffolk Counties, NY, were identified as potential cases. Population-based controls were frequency matched by 5-year age groups. Genotyping was performed with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) technology, and suspected breast cancer risk factors and usual dietary intake were assessed during an in-person interview. Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Having at least one A allele was associated with an overall 13% reduction in breast cancer risk. When consumption of fruits and vegetables and specific dietary antioxidants were dichotomized at the median, inverse associations with either GA or AA genotypes were most pronounced among women who consumed higher amounts of total fruits and vegetables (odds ratio, 0.75; 95% confidence interval, 0.58-0.97); this association was not noted among the low-consumption group (P for interaction = 0.04). Relationships were strongest among premenopausal women. Results from this first study of MPO genotypes and breast cancer risk indicate that MPO variants, related to reduced generation of ROS, are associated with decreased breast cancer risk, and emphasize the importance of fruit and vegetable consumption in reduction of breast cancer risk. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/15492293/Myeloperoxidase_genotype_fruit_and_vegetable_consumption_and_breast_cancer_risk_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=15492293 DB - PRIME DP - Unbound Medicine ER -