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A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes.
Biosens Bioelectron. 2004 Oct 15; 20(3):633-42.BB

Abstract

Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices.

Authors+Show Affiliations

Chien FC
Institute of Optical Sciences, National Central University, Chung-Li 320, Taiwan.
Chen SJ
No affiliation info available

MeSH

Computer SimulationEquipment Failure AnalysisModels, ChemicalProtein Interaction MappingRefractometryReproducibility of ResultsSensitivity and SpecificitySurface Plasmon Resonance

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15494249

Citation

Chien, F-C, and S-J Chen. "A Sensitivity Comparison of Optical Biosensors Based On Four Different Surface Plasmon Resonance Modes." Biosensors & Bioelectronics, vol. 20, no. 3, 2004, pp. 633-42.
Chien FC, Chen SJ. A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes. Biosens Bioelectron. 2004;20(3):633-42.
Chien, F. C., & Chen, S. J. (2004). A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes. Biosensors & Bioelectronics, 20(3), 633-42.
Chien FC, Chen SJ. A Sensitivity Comparison of Optical Biosensors Based On Four Different Surface Plasmon Resonance Modes. Biosens Bioelectron. 2004 Oct 15;20(3):633-42. PubMed PMID: 15494249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes. AU - Chien,F-C, AU - Chen,S-J, PY - 2004/01/15/received PY - 2004/03/05/revised PY - 2004/03/11/accepted PY - 2004/10/21/pubmed PY - 2005/5/25/medline PY - 2004/10/21/entrez SP - 633 EP - 42 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 20 IS - 3 N2 - Current surface plasmon resonance (SPR) modes based on the attenuated total reflection (ATR) method can broadly be categorized as: conventional SPR, long-range SPR (LRSPR), coupled plasmon-waveguide resonance (CPWR), and waveguide-coupled SPR (WCSPR). Although the features of optical biosensors are dependent upon their particular SPR mode, a common requirement for all biosensors utilized for biomolecular interaction analysis (BIA) is a high degree of sensitivity. The current paper presents a theoretical analysis and comparison of the sensitivity and resolution of these four types of SPR biosensors when employed in three of the most prevalent detection methods, namely angular interrogation, wavelength interrogation, and intensity measurement. This study develops a detailed understanding of the influences of various biosensor design parameters in order to enhance the sensitivity and detection limit capabilities of such devices. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/15494249/A_sensitivity_comparison_of_optical_biosensors_based_on_four_different_surface_plasmon_resonance_modes_ DB - PRIME DP - Unbound Medicine ER -