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Distant influences of amygdala lesion on visual cortical activation during emotional face processing.
Nat Neurosci. 2004 Nov; 7(11):1271-8.NN

Abstract

Emotional visual stimuli evoke enhanced responses in the visual cortex. To test whether this reflects modulatory influences from the amygdala on sensory processing, we used event-related functional magnetic resonance imaging (fMRI) in human patients with medial temporal lobe sclerosis. Twenty-six patients with lesions in the amygdala, the hippocampus or both, plus 13 matched healthy controls, were shown pictures of fearful or neutral faces in task-releant or task-irrelevant positions on the display. All subjects showed increased fusiform cortex activation when the faces were in task-relevant positions. Both healthy individuals and those with hippocampal damage showed increased activation in the fusiform and occipital cortex when they were shown fearful faces, but this was not the case for individuals with damage to the amygdala, even though visual areas were structurally intact. The distant influence of the amygdala was also evidenced by the parametric relationship between amygdala damage and the level of emotional activation in the fusiform cortex. Our data show that combining the fMRI and lesion approaches can help reveal the source of functional modulatory influences between distant but interconnected brain regions.

Authors+Show Affiliations

Laboratory for Neurology and Imaging of Cognition, Department of Neurology and Neurosciences, Centre Médical Universitaire, University of Geneva, 1211 Geneva 4, Switzerland. patrik.vuileumier@medicine.unige.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15494727

Citation

Vuilleumier, Patrik, et al. "Distant Influences of Amygdala Lesion On Visual Cortical Activation During Emotional Face Processing." Nature Neuroscience, vol. 7, no. 11, 2004, pp. 1271-8.
Vuilleumier P, Richardson MP, Armony JL, et al. Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat Neurosci. 2004;7(11):1271-8.
Vuilleumier, P., Richardson, M. P., Armony, J. L., Driver, J., & Dolan, R. J. (2004). Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nature Neuroscience, 7(11), 1271-8.
Vuilleumier P, et al. Distant Influences of Amygdala Lesion On Visual Cortical Activation During Emotional Face Processing. Nat Neurosci. 2004;7(11):1271-8. PubMed PMID: 15494727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distant influences of amygdala lesion on visual cortical activation during emotional face processing. AU - Vuilleumier,Patrik, AU - Richardson,Mark P, AU - Armony,Jorge L, AU - Driver,Jon, AU - Dolan,Raymond J, Y1 - 2004/10/24/ PY - 2004/05/03/received PY - 2004/09/21/accepted PY - 2004/10/21/pubmed PY - 2005/2/3/medline PY - 2004/10/21/entrez SP - 1271 EP - 8 JF - Nature neuroscience JO - Nat Neurosci VL - 7 IS - 11 N2 - Emotional visual stimuli evoke enhanced responses in the visual cortex. To test whether this reflects modulatory influences from the amygdala on sensory processing, we used event-related functional magnetic resonance imaging (fMRI) in human patients with medial temporal lobe sclerosis. Twenty-six patients with lesions in the amygdala, the hippocampus or both, plus 13 matched healthy controls, were shown pictures of fearful or neutral faces in task-releant or task-irrelevant positions on the display. All subjects showed increased fusiform cortex activation when the faces were in task-relevant positions. Both healthy individuals and those with hippocampal damage showed increased activation in the fusiform and occipital cortex when they were shown fearful faces, but this was not the case for individuals with damage to the amygdala, even though visual areas were structurally intact. The distant influence of the amygdala was also evidenced by the parametric relationship between amygdala damage and the level of emotional activation in the fusiform cortex. Our data show that combining the fMRI and lesion approaches can help reveal the source of functional modulatory influences between distant but interconnected brain regions. SN - 1097-6256 UR - https://www.unboundmedicine.com/medline/citation/15494727/Distant_influences_of_amygdala_lesion_on_visual_cortical_activation_during_emotional_face_processing_ L2 - https://doi.org/10.1038/nn1341 DB - PRIME DP - Unbound Medicine ER -