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Association of haplotypes in the beta-chemokine locus with multiple sclerosis.
Eur J Hum Genet 2005; 13(2):240-7EJ

Abstract

Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data from three genome scans suggested linkage. This region encodes a cluster of genes for beta-chemokines or CC chemokine ligands (CCLs), which may be involved in the development of MS lesions. Here we aimed to test if CCL alleles and haplotypes are associated with MS. Using methods of linkage and association, we observed deviations from the expected 50% transmission of haplotypes from unaffected parents to their affected children at CCL2, CCL11-CCL8-CCL13 and CCL3 within the investigated 1.85 MB chromosomal segment. Analyses of the linkage disequilibrium map support that variants with possible relevance to MS can be located within these subregions. Identification of MS associated CCL variants may have direct clinical significance, as it can lead to the design of small competitive antagonists of these molecules with beneficial effects in the treatment of patients with early and active disease.

Authors+Show Affiliations

Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15494740

Citation

Vyshkina, Tamara, et al. "Association of Haplotypes in the Beta-chemokine Locus With Multiple Sclerosis." European Journal of Human Genetics : EJHG, vol. 13, no. 2, 2005, pp. 240-7.
Vyshkina T, Shugart YY, Birnbaum G, et al. Association of haplotypes in the beta-chemokine locus with multiple sclerosis. Eur J Hum Genet. 2005;13(2):240-7.
Vyshkina, T., Shugart, Y. Y., Birnbaum, G., Leist, T. P., & Kalman, B. (2005). Association of haplotypes in the beta-chemokine locus with multiple sclerosis. European Journal of Human Genetics : EJHG, 13(2), pp. 240-7.
Vyshkina T, et al. Association of Haplotypes in the Beta-chemokine Locus With Multiple Sclerosis. Eur J Hum Genet. 2005;13(2):240-7. PubMed PMID: 15494740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of haplotypes in the beta-chemokine locus with multiple sclerosis. AU - Vyshkina,Tamara, AU - Shugart,Yin Yao, AU - Birnbaum,Gary, AU - Leist,Thomas P, AU - Kalman,Bernadette, PY - 2004/10/21/pubmed PY - 2005/7/6/medline PY - 2004/10/21/entrez SP - 240 EP - 7 JF - European journal of human genetics : EJHG JO - Eur. J. Hum. Genet. VL - 13 IS - 2 N2 - Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data from three genome scans suggested linkage. This region encodes a cluster of genes for beta-chemokines or CC chemokine ligands (CCLs), which may be involved in the development of MS lesions. Here we aimed to test if CCL alleles and haplotypes are associated with MS. Using methods of linkage and association, we observed deviations from the expected 50% transmission of haplotypes from unaffected parents to their affected children at CCL2, CCL11-CCL8-CCL13 and CCL3 within the investigated 1.85 MB chromosomal segment. Analyses of the linkage disequilibrium map support that variants with possible relevance to MS can be located within these subregions. Identification of MS associated CCL variants may have direct clinical significance, as it can lead to the design of small competitive antagonists of these molecules with beneficial effects in the treatment of patients with early and active disease. SN - 1018-4813 UR - https://www.unboundmedicine.com/medline/citation/15494740/Association_of_haplotypes_in_the_beta_chemokine_locus_with_multiple_sclerosis_ L2 - http://dx.doi.org/10.1038/sj.ejhg.5201295 DB - PRIME DP - Unbound Medicine ER -