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Investigation of the antibiotic susceptibility patterns of pathogens causing nosocomial infections.
Saudi Med J. 2004 Oct; 25(10):1403-9.SM

Abstract

OBJECTIVE

The aim of this study is to determine the resistance patterns of bacteria causing nosocomial infections. The outcome of this resistance was followed for 3 years.

METHODS

This study was carried out during 2000 to 2002 at a university hospital in Turkey. The resistance patterns of 570 bacteria (390 Gram-negative, 180 Gram-positive) against meropenem, imipenem, ceftazidime, cefotaxime, cefepime, piperacillin/tazobactam, ciprofloxacin and tobramycin were investigated using the E-test. Extended-spectrum beta-lactamase (ESBL) production was determined using ceftazidime and ceftazidime/clavulanic acid E-test strips.

RESULTS

Meropenem was the most effective antibiotic against Gram-negative organisms (89.0%); this was followed by imipenem (87.2%) and piperacillin/tazobactam (66.4%). The most active antibiotic against Gram-positive bacteria was imipenem (87.2%) and this was followed by piperacillin/tazobactam (81.7%) and meropenem (77.8%). The rates of production of ESBL by Escherichia coli were 20.9%, Klebsiella pneumoniae 50% and Serratia marcescens were 46.7%. Extended-spectrum beta-lactamase production increased each year (21.7%, 22.1% and 45.5%). All of the ESBL producing isolates were sensitive to meropenem and 98.5% sensitive to imipenem. AmpC beta-lactamase was produced by 20.9% of the Enterobacter species spp, Citrobacter spp. and Serratia marcescens. All of these were sensitive to meropenem and 77.8% to imipenem and ciprofloxacin. Multi-drug resistance rates in Acinetobacter spp were 45.4% and 37.7% in Pseudomonas aeruginosa isolates.

CONCLUSION

As in the entire world, resistance to antibiotics is a serious problem in our country. Solving of this problem depends primarily on prevention of the development of resistance.

Authors+Show Affiliations

Department of Microbiology, Faculty of Medicine, University of Cukurova, Adana, Turkey. kyaman@cu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15494811

Citation

Yaman, Akgun, et al. "Investigation of the Antibiotic Susceptibility Patterns of Pathogens Causing Nosocomial Infections." Saudi Medical Journal, vol. 25, no. 10, 2004, pp. 1403-9.
Yaman A, Tasova Y, Kibar F, et al. Investigation of the antibiotic susceptibility patterns of pathogens causing nosocomial infections. Saudi Med J. 2004;25(10):1403-9.
Yaman, A., Tasova, Y., Kibar, F., Inal, A. S., Saltoglu, N., Buyukcelik, O., Kurtaran, B., & Dundar, I. H. (2004). Investigation of the antibiotic susceptibility patterns of pathogens causing nosocomial infections. Saudi Medical Journal, 25(10), 1403-9.
Yaman A, et al. Investigation of the Antibiotic Susceptibility Patterns of Pathogens Causing Nosocomial Infections. Saudi Med J. 2004;25(10):1403-9. PubMed PMID: 15494811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of the antibiotic susceptibility patterns of pathogens causing nosocomial infections. AU - Yaman,Akgun, AU - Tasova,Yesim, AU - Kibar,Filiz, AU - Inal,Ayse S, AU - Saltoglu,Nese, AU - Buyukcelik,Ozlem, AU - Kurtaran,Behice, AU - Dundar,Ismail H, PY - 2004/10/21/pubmed PY - 2004/12/16/medline PY - 2004/10/21/entrez SP - 1403 EP - 9 JF - Saudi medical journal JO - Saudi Med J VL - 25 IS - 10 N2 - OBJECTIVE: The aim of this study is to determine the resistance patterns of bacteria causing nosocomial infections. The outcome of this resistance was followed for 3 years. METHODS: This study was carried out during 2000 to 2002 at a university hospital in Turkey. The resistance patterns of 570 bacteria (390 Gram-negative, 180 Gram-positive) against meropenem, imipenem, ceftazidime, cefotaxime, cefepime, piperacillin/tazobactam, ciprofloxacin and tobramycin were investigated using the E-test. Extended-spectrum beta-lactamase (ESBL) production was determined using ceftazidime and ceftazidime/clavulanic acid E-test strips. RESULTS: Meropenem was the most effective antibiotic against Gram-negative organisms (89.0%); this was followed by imipenem (87.2%) and piperacillin/tazobactam (66.4%). The most active antibiotic against Gram-positive bacteria was imipenem (87.2%) and this was followed by piperacillin/tazobactam (81.7%) and meropenem (77.8%). The rates of production of ESBL by Escherichia coli were 20.9%, Klebsiella pneumoniae 50% and Serratia marcescens were 46.7%. Extended-spectrum beta-lactamase production increased each year (21.7%, 22.1% and 45.5%). All of the ESBL producing isolates were sensitive to meropenem and 98.5% sensitive to imipenem. AmpC beta-lactamase was produced by 20.9% of the Enterobacter species spp, Citrobacter spp. and Serratia marcescens. All of these were sensitive to meropenem and 77.8% to imipenem and ciprofloxacin. Multi-drug resistance rates in Acinetobacter spp were 45.4% and 37.7% in Pseudomonas aeruginosa isolates. CONCLUSION: As in the entire world, resistance to antibiotics is a serious problem in our country. Solving of this problem depends primarily on prevention of the development of resistance. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/15494811/Investigation_of_the_antibiotic_susceptibility_patterns_of_pathogens_causing_nosocomial_infections_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -