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Prevalence of human T-lymphotropic virus type I and type II antibody among blood donors in Eastern Saudi Arabia.
Saudi Med J. 2004 Oct; 25(10):1419-22.SM

Abstract

OBJECTIVE

Human T-cell leukemia/lymphoma virus type I and type II (HTLV-I/II) infections can be transfusion associated, leading to tropical paraparesis, myelopathy and other neurological disorders. The aim of this study is to circumvent the risk of transmission through blood transfusion and to describe the prevalence of HTLV-I/II antibody among blood donors of Al-Hasa region and the cost effectiveness of screening blood donors.

METHODS

The study was conducted at the Department of Laboratory and Blood Bank, King Fahad Hospital, Al-Hofuf, Al-Hasa, Kingdom of Saudi Arabia during the period of 1997 to 2003. A total of 47426 blood donors were screened for HTLV-I/II antibody by enzyme-linked immunosorbent assay test, during the 7 years of study period. The positive samples were confirmed by western blot analysis.

RESULTS

Overall, HTLV-I antibody positivity (confirmed by western blot) was 3/47426 (0.006%). Out of 3 donors positive for HTLV-I antibody during 1997 to 1998, 2 were expatriates (Indian) and one was native Saudi donor. Human T-cell leukemia/lymphoma virus type I antibody positivity among the native Saudi donors was 1/47426 (0.002%) (2/100000 blood donors). None of the donor were positive for HTLV-II antibody. During the last 5 consecutive years of the study period (1999-2003), none of the donor was positive for HTLV-I/II antibody.

CONCLUSION

Al-Hasa region is non-endemic for HTLV-I/II virus infections. Screening of native Saudi blood donors for these viruses does not appear to be cost effective.

Authors+Show Affiliations

Department of Laboratory and Blood Bank, King Fahad Hospital and Tertiary Care Center, Al-Hofuf, Al-Hasa, Kingdom of Saudi Arabia.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15494814

Citation

Ul-Hassan, Zahoor, et al. "Prevalence of Human T-lymphotropic Virus Type I and Type II Antibody Among Blood Donors in Eastern Saudi Arabia." Saudi Medical Journal, vol. 25, no. 10, 2004, pp. 1419-22.
Ul-Hassan Z, Al-Bahrani AT, Panhotra BR. Prevalence of human T-lymphotropic virus type I and type II antibody among blood donors in Eastern Saudi Arabia. Saudi Med J. 2004;25(10):1419-22.
Ul-Hassan, Z., Al-Bahrani, A. T., & Panhotra, B. R. (2004). Prevalence of human T-lymphotropic virus type I and type II antibody among blood donors in Eastern Saudi Arabia. Saudi Medical Journal, 25(10), 1419-22.
Ul-Hassan Z, Al-Bahrani AT, Panhotra BR. Prevalence of Human T-lymphotropic Virus Type I and Type II Antibody Among Blood Donors in Eastern Saudi Arabia. Saudi Med J. 2004;25(10):1419-22. PubMed PMID: 15494814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of human T-lymphotropic virus type I and type II antibody among blood donors in Eastern Saudi Arabia. AU - Ul-Hassan,Zahoor, AU - Al-Bahrani,Ahmad T, AU - Panhotra,Bodh R, PY - 2004/10/21/pubmed PY - 2004/12/16/medline PY - 2004/10/21/entrez SP - 1419 EP - 22 JF - Saudi medical journal JO - Saudi Med J VL - 25 IS - 10 N2 - OBJECTIVE: Human T-cell leukemia/lymphoma virus type I and type II (HTLV-I/II) infections can be transfusion associated, leading to tropical paraparesis, myelopathy and other neurological disorders. The aim of this study is to circumvent the risk of transmission through blood transfusion and to describe the prevalence of HTLV-I/II antibody among blood donors of Al-Hasa region and the cost effectiveness of screening blood donors. METHODS: The study was conducted at the Department of Laboratory and Blood Bank, King Fahad Hospital, Al-Hofuf, Al-Hasa, Kingdom of Saudi Arabia during the period of 1997 to 2003. A total of 47426 blood donors were screened for HTLV-I/II antibody by enzyme-linked immunosorbent assay test, during the 7 years of study period. The positive samples were confirmed by western blot analysis. RESULTS: Overall, HTLV-I antibody positivity (confirmed by western blot) was 3/47426 (0.006%). Out of 3 donors positive for HTLV-I antibody during 1997 to 1998, 2 were expatriates (Indian) and one was native Saudi donor. Human T-cell leukemia/lymphoma virus type I antibody positivity among the native Saudi donors was 1/47426 (0.002%) (2/100000 blood donors). None of the donor were positive for HTLV-II antibody. During the last 5 consecutive years of the study period (1999-2003), none of the donor was positive for HTLV-I/II antibody. CONCLUSION: Al-Hasa region is non-endemic for HTLV-I/II virus infections. Screening of native Saudi blood donors for these viruses does not appear to be cost effective. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/15494814/Prevalence_of_human_T_lymphotropic_virus_type_I_and_type_II_antibody_among_blood_donors_in_Eastern_Saudi_Arabia_ L2 - https://medlineplus.gov/bloodtransfusionanddonation.html DB - PRIME DP - Unbound Medicine ER -