Tags

Type your tag names separated by a space and hit enter

A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus.
Clin Infect Dis. 2004 Nov 01; 39(9):1329-35.CI

Abstract

BACKGROUND

Scrub typhus is one of the most important endemic infections in the Asia-Pacific region. Although tetracyclines or chloramphenicol are the recommended drugs of choice for the treatment of scrub typhus, reports of doxycycline-resistant strains have prompted a search for alternative treatments.

METHODS

We conducted a prospective, open-label, randomized trial from September 2002 through November 2003 to compare azithromycin with doxycycline for the treatment of mild scrub typhus. The time to defervescence was assessed to compare the efficacy of the 2 treatment regimens.

RESULTS

A total of 93 patients were randomly assigned to receive either a single 500-mg dose of azithromycin or a 1-week course of daily oral 200-mg dose of doxycycline. Cure was achieved in 47 (100%) of 47 patients in the azithromycin-treated group and in 43 (93.5%) of 46 patients in the doxycycline-treated group (P=.117). The median time to defervescence was 21 h for the azithromycin-treated group and 29 h for the doxycycline-treated group (P=.097). There were no serious adverse events during the study. No relapses occurred in either group during a 1-month follow-up period.

CONCLUSION

The single 500-mg dose of azithromycin was as effective as the 1-week course of daily 200-mg doses of doxycycline for the treatment of mild scrub typhus acquired in South Korea.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University Hospital, Jung-gu, Daejeon, Korea. alice@cnuh.co.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15494910

Citation

Kim, Yeon-Sook, et al. "A Comparative Trial of a Single Dose of Azithromycin Versus Doxycycline for the Treatment of Mild Scrub Typhus." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 39, no. 9, 2004, pp. 1329-35.
Kim YS, Yun HJ, Shim SK, et al. A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. Clin Infect Dis. 2004;39(9):1329-35.
Kim, Y. S., Yun, H. J., Shim, S. K., Koo, S. H., Kim, S. Y., & Kim, S. (2004). A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 39(9), 1329-35.
Kim YS, et al. A Comparative Trial of a Single Dose of Azithromycin Versus Doxycycline for the Treatment of Mild Scrub Typhus. Clin Infect Dis. 2004 Nov 1;39(9):1329-35. PubMed PMID: 15494910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative trial of a single dose of azithromycin versus doxycycline for the treatment of mild scrub typhus. AU - Kim,Yeon-Sook, AU - Yun,Hwan-Jung, AU - Shim,Soo Kyoung, AU - Koo,Sun Hoe, AU - Kim,Sun Young, AU - Kim,Samyong, Y1 - 2004/10/11/ PY - 2004/04/25/received PY - 2004/06/24/accepted PY - 2004/10/21/pubmed PY - 2006/10/13/medline PY - 2004/10/21/entrez SP - 1329 EP - 35 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 39 IS - 9 N2 - BACKGROUND: Scrub typhus is one of the most important endemic infections in the Asia-Pacific region. Although tetracyclines or chloramphenicol are the recommended drugs of choice for the treatment of scrub typhus, reports of doxycycline-resistant strains have prompted a search for alternative treatments. METHODS: We conducted a prospective, open-label, randomized trial from September 2002 through November 2003 to compare azithromycin with doxycycline for the treatment of mild scrub typhus. The time to defervescence was assessed to compare the efficacy of the 2 treatment regimens. RESULTS: A total of 93 patients were randomly assigned to receive either a single 500-mg dose of azithromycin or a 1-week course of daily oral 200-mg dose of doxycycline. Cure was achieved in 47 (100%) of 47 patients in the azithromycin-treated group and in 43 (93.5%) of 46 patients in the doxycycline-treated group (P=.117). The median time to defervescence was 21 h for the azithromycin-treated group and 29 h for the doxycycline-treated group (P=.097). There were no serious adverse events during the study. No relapses occurred in either group during a 1-month follow-up period. CONCLUSION: The single 500-mg dose of azithromycin was as effective as the 1-week course of daily 200-mg doses of doxycycline for the treatment of mild scrub typhus acquired in South Korea. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15494910/A_comparative_trial_of_a_single_dose_of_azithromycin_versus_doxycycline_for_the_treatment_of_mild_scrub_typhus_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/425008 DB - PRIME DP - Unbound Medicine ER -