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Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis.
Mass Spectrom Rev. 2005 Sep-Oct; 24(5):661-700.MS

Abstract

Selected ion flow tube mass spectrometry (SIFT-MS) is a new analytical technique for the real-time quantification of several trace gases simultaneously in air and breath. It relies on chemical ionization of the trace gas molecules in air/breath samples introduced into helium carrier gas using H(3)O(+), NO(+), and O(2) (+.) precursor ions. Reactions between the precursor ions and trace gas molecules proceed for an accurately defined time, the precursor and product ions being detected and counted by a downstream mass spectrometer, thus effecting quantification. Absolute concentrations of trace gases in single breath exhalation can be determined by SIFT-MS down to ppb levels, obviating sample collection and calibration. Illustrative examples of SIFT-MS studies include (i) analysis of gases from combustion engines, animals and their waste, and food; (ii) breath and urinary headspace studies of metabolites, ethanol metabolism, elevated acetone during ovulation, and exogenous compounds; and (iii) urinary infection and the presence of tumors, the influence of dialysis on breath ammonia, acetone, and isoprene, and acetaldehyde released by cancer cells in vitro. Flowing afterglow mass spectrometry (FA-MS) is briefly described, which allows on-line quantification of deuterium in breath water vapor.

Authors+Show Affiliations

Institute of Science and Technology in Medicine, School of Medicine, University of Keele, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, United Kingdom. d.smith@bemp.keele.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15495143

Citation

Smith, David, and Patrik Spanel. "Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) for On-line Trace Gas Analysis." Mass Spectrometry Reviews, vol. 24, no. 5, 2005, pp. 661-700.
Smith D, Spanel P. Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrom Rev. 2005;24(5):661-700.
Smith, D., & Spanel, P. (2005). Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. Mass Spectrometry Reviews, 24(5), 661-700.
Smith D, Spanel P. Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) for On-line Trace Gas Analysis. Mass Spectrom Rev. 2005 Sep-Oct;24(5):661-700. PubMed PMID: 15495143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selected ion flow tube mass spectrometry (SIFT-MS) for on-line trace gas analysis. AU - Smith,David, AU - Spanel,Patrik, PY - 2004/10/21/pubmed PY - 2005/9/21/medline PY - 2004/10/21/entrez SP - 661 EP - 700 JF - Mass spectrometry reviews JO - Mass Spectrom Rev VL - 24 IS - 5 N2 - Selected ion flow tube mass spectrometry (SIFT-MS) is a new analytical technique for the real-time quantification of several trace gases simultaneously in air and breath. It relies on chemical ionization of the trace gas molecules in air/breath samples introduced into helium carrier gas using H(3)O(+), NO(+), and O(2) (+.) precursor ions. Reactions between the precursor ions and trace gas molecules proceed for an accurately defined time, the precursor and product ions being detected and counted by a downstream mass spectrometer, thus effecting quantification. Absolute concentrations of trace gases in single breath exhalation can be determined by SIFT-MS down to ppb levels, obviating sample collection and calibration. Illustrative examples of SIFT-MS studies include (i) analysis of gases from combustion engines, animals and their waste, and food; (ii) breath and urinary headspace studies of metabolites, ethanol metabolism, elevated acetone during ovulation, and exogenous compounds; and (iii) urinary infection and the presence of tumors, the influence of dialysis on breath ammonia, acetone, and isoprene, and acetaldehyde released by cancer cells in vitro. Flowing afterglow mass spectrometry (FA-MS) is briefly described, which allows on-line quantification of deuterium in breath water vapor. SN - 0277-7037 UR - https://www.unboundmedicine.com/medline/citation/15495143/Selected_ion_flow_tube_mass_spectrometry__SIFT_MS__for_on_line_trace_gas_analysis_ L2 - https://doi.org/10.1002/mas.20033 DB - PRIME DP - Unbound Medicine ER -