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Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma.
Cancer. 2004 Dec 15; 101(12):2744-54.C

Abstract

BACKGROUND

An effect of fatty acids has been implicated in men with advanced-stage prostate carcinoma and in men who have died of the disease. To evaluate the influence of fatty acids in men with prostate carcinoma at earlier stages, the authors examined the relation between prostatic concentrations of fatty acids and locally advanced prostate carcinoma in men with clinically organ-confined disease.

METHODS

Fatty acids were measured by capillary gas chromatography in fresh, nonmalignant prostate tissue specimens collected during surgery from 196 men undergoing radical prostatectomy for localized prostate carcinoma. Two-sided, two-sample Student t tests compared mean concentrations in men with extraprostatic disease (pT3-4N0-1M0) with control men with organ-confined disease. Logistic regression accounted for clinical stage, prostate-specific antigen level, Gleason sum, and other factors.

RESULTS

Percent total prostatic polyunsaturated fatty acid (PUFA) was found to be inversely associated with risk of locally advanced prostate carcinoma (n=52) (odds ratio [OR]=0.93, 95% confidence interval [95% CI], 0.87-0.99; P=0.035). Risk of seminal vesicle involvement accounted for this association (OR=0.86, 95% CI, 0.78-0.95; P=0.003). Percent omega-3 fatty acid (eicosapentanoic + docosahexanoic acids) and percent arachidonic acid also were found to be inversely related to the risk of seminal vesicle involvement (OR=0.52, 95% CI, 0.30-0.90; P=0.02; and OR=0.84, 95% CI,; 0.75-0.95; P=0.005, respectively).

CONCLUSIONS

Prostatic PUFA levels appear to influence the risk of locally advanced prostate carcinoma in men with clinically organ-confined disease. This association may be mediated through the immune system.

Authors+Show Affiliations

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612-4336, USA. Freem981@uic.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15495177

Citation

Freeman, Vincent L., et al. "Inverse Association Between Prostatic Polyunsaturated Fatty Acid and Risk of Locally Advanced Prostate Carcinoma." Cancer, vol. 101, no. 12, 2004, pp. 2744-54.
Freeman VL, Meydani M, Hur K, et al. Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma. Cancer. 2004;101(12):2744-54.
Freeman, V. L., Meydani, M., Hur, K., & Flanigan, R. C. (2004). Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma. Cancer, 101(12), 2744-54.
Freeman VL, et al. Inverse Association Between Prostatic Polyunsaturated Fatty Acid and Risk of Locally Advanced Prostate Carcinoma. Cancer. 2004 Dec 15;101(12):2744-54. PubMed PMID: 15495177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma. AU - Freeman,Vincent L, AU - Meydani,Mohsen, AU - Hur,Kwan, AU - Flanigan,Robert C, PY - 2004/10/21/pubmed PY - 2004/12/31/medline PY - 2004/10/21/entrez SP - 2744 EP - 54 JF - Cancer JO - Cancer VL - 101 IS - 12 N2 - BACKGROUND: An effect of fatty acids has been implicated in men with advanced-stage prostate carcinoma and in men who have died of the disease. To evaluate the influence of fatty acids in men with prostate carcinoma at earlier stages, the authors examined the relation between prostatic concentrations of fatty acids and locally advanced prostate carcinoma in men with clinically organ-confined disease. METHODS: Fatty acids were measured by capillary gas chromatography in fresh, nonmalignant prostate tissue specimens collected during surgery from 196 men undergoing radical prostatectomy for localized prostate carcinoma. Two-sided, two-sample Student t tests compared mean concentrations in men with extraprostatic disease (pT3-4N0-1M0) with control men with organ-confined disease. Logistic regression accounted for clinical stage, prostate-specific antigen level, Gleason sum, and other factors. RESULTS: Percent total prostatic polyunsaturated fatty acid (PUFA) was found to be inversely associated with risk of locally advanced prostate carcinoma (n=52) (odds ratio [OR]=0.93, 95% confidence interval [95% CI], 0.87-0.99; P=0.035). Risk of seminal vesicle involvement accounted for this association (OR=0.86, 95% CI, 0.78-0.95; P=0.003). Percent omega-3 fatty acid (eicosapentanoic + docosahexanoic acids) and percent arachidonic acid also were found to be inversely related to the risk of seminal vesicle involvement (OR=0.52, 95% CI, 0.30-0.90; P=0.02; and OR=0.84, 95% CI,; 0.75-0.95; P=0.005, respectively). CONCLUSIONS: Prostatic PUFA levels appear to influence the risk of locally advanced prostate carcinoma in men with clinically organ-confined disease. This association may be mediated through the immune system. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15495177/Inverse_association_between_prostatic_polyunsaturated_fatty_acid_and_risk_of_locally_advanced_prostate_carcinoma_ L2 - https://doi.org/10.1002/cncr.20676 DB - PRIME DP - Unbound Medicine ER -