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The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice.
Eur J Pharmacol. 2004 Oct 25; 503(1-3):103-7.EJ

Abstract

Phencyclidine has frequently been used to model schizophrenia in animals. In the present study, the ability of the neuronal selective nitric oxide synthase (NOS) inhibitor, Nomega-propyl-L-arginine, to block the behavioural effects of phencyclidine in mice was investigated. N(omega)-propyl-L-arginine (20 mg/kg) was found to block both phencyclidine (4 mg/kg)-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity in the mice tested. It is concluded that the NOS-sensitive behavioural effects of phencyclidine in rodents is dependent on neuronal NOS and that NO may play a role in the psychotomimetic effects of phencyclidine.

Authors+Show Affiliations

Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, POB 431, SE 405 30 Göteborg, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15496304

Citation

Klamer, Daniel, et al. "The Neuronal Selective Nitric Oxide Synthase Inhibitor, Nomega-propyl-L-arginine, Blocks the Effects of Phencyclidine On Prepulse Inhibition and Locomotor Activity in Mice." European Journal of Pharmacology, vol. 503, no. 1-3, 2004, pp. 103-7.
Klamer D, Engel JA, Svensson L. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004;503(1-3):103-7.
Klamer, D., Engel, J. A., & Svensson, L. (2004). The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. European Journal of Pharmacology, 503(1-3), 103-7.
Klamer D, Engel JA, Svensson L. The Neuronal Selective Nitric Oxide Synthase Inhibitor, Nomega-propyl-L-arginine, Blocks the Effects of Phencyclidine On Prepulse Inhibition and Locomotor Activity in Mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. PubMed PMID: 15496304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. AU - Klamer,Daniel, AU - Engel,Jörgen A, AU - Svensson,Lennart, PY - 2004/09/06/received PY - 2004/09/10/accepted PY - 2004/10/22/pubmed PY - 2005/4/26/medline PY - 2004/10/22/entrez SP - 103 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 503 IS - 1-3 N2 - Phencyclidine has frequently been used to model schizophrenia in animals. In the present study, the ability of the neuronal selective nitric oxide synthase (NOS) inhibitor, Nomega-propyl-L-arginine, to block the behavioural effects of phencyclidine in mice was investigated. N(omega)-propyl-L-arginine (20 mg/kg) was found to block both phencyclidine (4 mg/kg)-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity in the mice tested. It is concluded that the NOS-sensitive behavioural effects of phencyclidine in rodents is dependent on neuronal NOS and that NO may play a role in the psychotomimetic effects of phencyclidine. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15496304/The_neuronal_selective_nitric_oxide_synthase_inhibitor_Nomega_propyl_L_arginine_blocks_the_effects_of_phencyclidine_on_prepulse_inhibition_and_locomotor_activity_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(04)01079-9 DB - PRIME DP - Unbound Medicine ER -