Tags

Type your tag names separated by a space and hit enter

Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension.
Eur J Pharmacol. 2004 Oct 25; 503(1-3):129-33.EJ

Abstract

The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP). Newborn male Wistar rats were injected with either capsaicin or vehicle. After weaning at 3 weeks, these rats were divided into the following six treatment groups: capsaicin plus high-salt diet (CAP+HS), control plus high-salt diet (CON+HS), control plus normal salt diet (CON+NS), capsaicin plus high-salt diet and telmisartan (CAP+HS+T, 10 mg/kg/day), capsaicin plus high-salt diet and perindopril (CAP+HS+P, 2 mg/kg/day), and capsaicin plus high-salt diet and spironolactone (CAP+HS+S, 80 mg/kg/day). Treatment with different salt diets and drugs was initiated at 3 weeks of age and lasted 18 weeks. We found that beginning at the second week after the initiation of the treatment, blood pressure became significantly higher in CAP+HS than in other groups, accompanied by the development of cardiac hypertrophy. Treatment with telmisartan, perindopril or spironolactone prevented the development of hypertension in the CAP+HS group. Cardiac hypertrophy was prevented in the perindopril treatment group. The medial thickness, media-to-lumen ratio and cross-sectional area of the thoracic, renal and mesenteric arteries were significantly increased in CAP+HS than in other groups. Lumen diameter was similar in all the vessels among all the groups. Treatment with telmisartan, perindopril or spironolactone prevented the development of vascular remodeling, as found in the CAP+HS group. Beginning at 8 weeks after the initiation of the salt diet treatment (11 weeks of age), blood pressure also became higher in CON+HS than in CON+NS, but lower than CAP+HS. Structural changes of vessels were also present in CON+HS, but the degree of change was less when compared with CAP+HS. We conclude that neonatal treatment with capsaicin plus a high-salt diet, and a high-salt diet alone both induced hypertension development in normal Wistar rats, which are associated with cardiovascular remodeling. The renin-angiotensin-aldosterone system is involved in this salt-sensitive model because treatment that interfered with this system also prevented the development of hypertension and vascular remodeling.

Authors+Show Affiliations

Smooth Muscle Research Program and Department of Anesthesia, McMaster University, Department of Anesthesiology (HSC-2u3), 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15496307

Citation

Zeng, Zhao-Hua, et al. "Control of Vascular Changes By Renin-angiotensin-aldosterone System in Salt-sensitive Hypertension." European Journal of Pharmacology, vol. 503, no. 1-3, 2004, pp. 129-33.
Zeng ZH, Luo BH, Gao YJ, et al. Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension. Eur J Pharmacol. 2004;503(1-3):129-33.
Zeng, Z. H., Luo, B. H., Gao, Y. J., Su, C. J., He, C. C., Yi, J. J., Li, N., & Lee, R. M. (2004). Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension. European Journal of Pharmacology, 503(1-3), 129-33.
Zeng ZH, et al. Control of Vascular Changes By Renin-angiotensin-aldosterone System in Salt-sensitive Hypertension. Eur J Pharmacol. 2004 Oct 25;503(1-3):129-33. PubMed PMID: 15496307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Control of vascular changes by renin-angiotensin-aldosterone system in salt-sensitive hypertension. AU - Zeng,Zhao-Hua, AU - Luo,Bi-Hui, AU - Gao,Yu-Jing, AU - Su,Cheng-Jian, AU - He,Chao-Chu, AU - Yi,Jia-Ji, AU - Li,Nina, AU - Lee,Robert M K W, PY - 2004/05/24/received PY - 2004/09/06/revised PY - 2004/09/07/accepted PY - 2004/10/22/pubmed PY - 2005/4/26/medline PY - 2004/10/22/entrez SP - 129 EP - 33 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 503 IS - 1-3 N2 - The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP). Newborn male Wistar rats were injected with either capsaicin or vehicle. After weaning at 3 weeks, these rats were divided into the following six treatment groups: capsaicin plus high-salt diet (CAP+HS), control plus high-salt diet (CON+HS), control plus normal salt diet (CON+NS), capsaicin plus high-salt diet and telmisartan (CAP+HS+T, 10 mg/kg/day), capsaicin plus high-salt diet and perindopril (CAP+HS+P, 2 mg/kg/day), and capsaicin plus high-salt diet and spironolactone (CAP+HS+S, 80 mg/kg/day). Treatment with different salt diets and drugs was initiated at 3 weeks of age and lasted 18 weeks. We found that beginning at the second week after the initiation of the treatment, blood pressure became significantly higher in CAP+HS than in other groups, accompanied by the development of cardiac hypertrophy. Treatment with telmisartan, perindopril or spironolactone prevented the development of hypertension in the CAP+HS group. Cardiac hypertrophy was prevented in the perindopril treatment group. The medial thickness, media-to-lumen ratio and cross-sectional area of the thoracic, renal and mesenteric arteries were significantly increased in CAP+HS than in other groups. Lumen diameter was similar in all the vessels among all the groups. Treatment with telmisartan, perindopril or spironolactone prevented the development of vascular remodeling, as found in the CAP+HS group. Beginning at 8 weeks after the initiation of the salt diet treatment (11 weeks of age), blood pressure also became higher in CON+HS than in CON+NS, but lower than CAP+HS. Structural changes of vessels were also present in CON+HS, but the degree of change was less when compared with CAP+HS. We conclude that neonatal treatment with capsaicin plus a high-salt diet, and a high-salt diet alone both induced hypertension development in normal Wistar rats, which are associated with cardiovascular remodeling. The renin-angiotensin-aldosterone system is involved in this salt-sensitive model because treatment that interfered with this system also prevented the development of hypertension and vascular remodeling. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15496307/Control_of_vascular_changes_by_renin_angiotensin_aldosterone_system_in_salt_sensitive_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(04)01045-3 DB - PRIME DP - Unbound Medicine ER -