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High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats.
Sheng Li Xue Bao. 2004 Oct 25; 56(5):620-4.SL

Abstract

The effects of femoral nerve electrostimulation (FNES) on ischemia-reperfused myocardium were examined in the urethane- anesthetized rats to determine whether FNES may provide cardioprotection and to observe the possible mechanism. The area at risk (AR) and infarct area (IA) were determined using Evans blue and nitro-blue tetrazolium staining, respectively. Infarct size (IS) was defined as 100xIA/AR (%). The results are as follows: (1) During 30 min myocardial ischemia and subsequent 120 min reperfusion, the myocardial infarct size occupied (54.96+/-0.82)% of the area at risk. (2) FNES of high frequency (10 V, 100 Hz, 1 ms) significantly reduced myocardial infarct size to (36.94+/-1.34)% (P<0.01), indicating the cardioprotective effect FNES of high frequency on myocardial ischemia-reperfusion, while FNES of low frequency (10 V, 10 Hz, 1 ms) had no effect on myocardial infarct size. (3) Pretreatment with either naloxone (5 mg /kg, i.v), a nonselective opioid receptor antagonist, or glibenclamide (5 mg /kg, i.v), a K(ATP) channel antagonist, completely abolished the cardioprotection of FNES (100 Hz) from myocardial ischemia-reperfusion. It is suggested that FNES of high frequency can protect myocardium from ischemia-reperfusion injury. The possible mechanism is that FNES of high frequency may induce the release of opioids from the central nervous system, and the activation of opioid receptors in the heart results in an opening of myocardial K(ATP) channels which can protect myocardium.

Authors+Show Affiliations

Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15497044

Citation

Dong, Jing-Hui, et al. "High-frequency Electrical Stimulation of Femoral Nerve Reduces Infarct Size Following Myocardial Ischemia-reperfusion in Rats." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 56, no. 5, 2004, pp. 620-4.
Dong JH, Liu YX, Zhao J, et al. High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats. Sheng Li Xue Bao. 2004;56(5):620-4.
Dong, J. H., Liu, Y. X., Zhao, J., Ma, H. J., Guo, S. M., & He, R. R. (2004). High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats. Sheng Li Xue Bao : [Acta Physiologica Sinica], 56(5), 620-4.
Dong JH, et al. High-frequency Electrical Stimulation of Femoral Nerve Reduces Infarct Size Following Myocardial Ischemia-reperfusion in Rats. Sheng Li Xue Bao. 2004 Oct 25;56(5):620-4. PubMed PMID: 15497044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-frequency electrical stimulation of femoral nerve reduces infarct size following myocardial ischemia-reperfusion in rats. AU - Dong,Jing-Hui, AU - Liu,Yi-Xian, AU - Zhao,Juan, AU - Ma,Hui-Jie, AU - Guo,Shu-Mei, AU - He,Rui-Rong, PY - 2004/10/22/pubmed PY - 2005/8/17/medline PY - 2004/10/22/entrez SP - 620 EP - 4 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 56 IS - 5 N2 - The effects of femoral nerve electrostimulation (FNES) on ischemia-reperfused myocardium were examined in the urethane- anesthetized rats to determine whether FNES may provide cardioprotection and to observe the possible mechanism. The area at risk (AR) and infarct area (IA) were determined using Evans blue and nitro-blue tetrazolium staining, respectively. Infarct size (IS) was defined as 100xIA/AR (%). The results are as follows: (1) During 30 min myocardial ischemia and subsequent 120 min reperfusion, the myocardial infarct size occupied (54.96+/-0.82)% of the area at risk. (2) FNES of high frequency (10 V, 100 Hz, 1 ms) significantly reduced myocardial infarct size to (36.94+/-1.34)% (P<0.01), indicating the cardioprotective effect FNES of high frequency on myocardial ischemia-reperfusion, while FNES of low frequency (10 V, 10 Hz, 1 ms) had no effect on myocardial infarct size. (3) Pretreatment with either naloxone (5 mg /kg, i.v), a nonselective opioid receptor antagonist, or glibenclamide (5 mg /kg, i.v), a K(ATP) channel antagonist, completely abolished the cardioprotection of FNES (100 Hz) from myocardial ischemia-reperfusion. It is suggested that FNES of high frequency can protect myocardium from ischemia-reperfusion injury. The possible mechanism is that FNES of high frequency may induce the release of opioids from the central nervous system, and the activation of opioid receptors in the heart results in an opening of myocardial K(ATP) channels which can protect myocardium. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/15497044/High_frequency_electrical_stimulation_of_femoral_nerve_reduces_infarct_size_following_myocardial_ischemia_reperfusion_in_rats_ L2 - http://www.actaps.com.cn/paper/200405/620.pdf DB - PRIME DP - Unbound Medicine ER -