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C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes.
Ann Neurol 2004; 56(6):827-35AN

Abstract

We examined the effects of C-peptide replacement on unmyelinated fiber function in the hind paw, sural nerve C-fiber morphometry, sciatic nerve neurotrophins, and the expression of neurotrophic receptors and content of neuropeptides in dorsal root ganglia in type 1 diabetic BB/Wor-rats. C-peptide replacement from onset of diabetes had no effect on hyperglycemia, but it significantly prevented progressive thermal hyperalgesia and prevented C-fiber atrophy, degeneration, and loss. These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells. These beneficial effects translated into prevention of the decreased content of dorsal root ganglia nociceptive peptides such as substance P and calcitonin gene-related peptide. From these findings we conclude that replacement of insulinomimetic C-peptide prevents abnormalities of neurotrophins, their receptors, and nociceptive neuropeptides in type 1 BB/Wor-rats, resulting in the prevention of C-fiber pathology and nociceptive sensory nerve dysfunction. The data indicate that perturbed insulin/C-peptide action plays an important pathogenetic role in nociceptive sensory neuropathy and that C-peptide replacement may be of benefit in treating painful diabetic neuropathy in insulin-deficient diabetic conditions.

Authors+Show Affiliations

Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15497155

Citation

Kamiya, Hideki, et al. "C-peptide Prevents Nociceptive Sensory Neuropathy in Type 1 Diabetes." Annals of Neurology, vol. 56, no. 6, 2004, pp. 827-35.
Kamiya H, Zhang W, Sima AA. C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes. Ann Neurol. 2004;56(6):827-35.
Kamiya, H., Zhang, W., & Sima, A. A. (2004). C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes. Annals of Neurology, 56(6), pp. 827-35.
Kamiya H, Zhang W, Sima AA. C-peptide Prevents Nociceptive Sensory Neuropathy in Type 1 Diabetes. Ann Neurol. 2004;56(6):827-35. PubMed PMID: 15497155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes. AU - Kamiya,Hideki, AU - Zhang,Weixian, AU - Sima,Anders A F, PY - 2004/10/22/pubmed PY - 2005/1/12/medline PY - 2004/10/22/entrez SP - 827 EP - 35 JF - Annals of neurology JO - Ann. Neurol. VL - 56 IS - 6 N2 - We examined the effects of C-peptide replacement on unmyelinated fiber function in the hind paw, sural nerve C-fiber morphometry, sciatic nerve neurotrophins, and the expression of neurotrophic receptors and content of neuropeptides in dorsal root ganglia in type 1 diabetic BB/Wor-rats. C-peptide replacement from onset of diabetes had no effect on hyperglycemia, but it significantly prevented progressive thermal hyperalgesia and prevented C-fiber atrophy, degeneration, and loss. These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells. These beneficial effects translated into prevention of the decreased content of dorsal root ganglia nociceptive peptides such as substance P and calcitonin gene-related peptide. From these findings we conclude that replacement of insulinomimetic C-peptide prevents abnormalities of neurotrophins, their receptors, and nociceptive neuropeptides in type 1 BB/Wor-rats, resulting in the prevention of C-fiber pathology and nociceptive sensory nerve dysfunction. The data indicate that perturbed insulin/C-peptide action plays an important pathogenetic role in nociceptive sensory neuropathy and that C-peptide replacement may be of benefit in treating painful diabetic neuropathy in insulin-deficient diabetic conditions. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/15497155/C_peptide_prevents_nociceptive_sensory_neuropathy_in_type_1_diabetes_ L2 - https://doi.org/10.1002/ana.20295 DB - PRIME DP - Unbound Medicine ER -