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Leptin and its association with polycystic ovary syndrome: a twin study.
Gynecol Endocrinol 2004; 18(6):327-34GE

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with symptoms such as obesity, insulin resistance and hyperandrogenemia. PCOS might be the result of a genetic disorder. Genetic discrepancy in the production of leptin, a product of the obesity gene, may lead to various endocrinopathies such as PCOS. The objective of this study was first, to ascertain the incidence of PCOS, using the gold standard; second, to ascertain the genetic property of leptin; and third, to evaluate the association between leptin concentration and PCOS. A total of 154 Tehran-resident female-female twins were studied. They included 48 pairs of monozygotic (MZ) and 29 pairs of dyzygotic (DZ) twins, aged 15-45 years. Clinical, ultrasound and biochemical findings were used to diagnose PCOS. The incidence of PCOS using biochemical and clinical features was 16.2%. The correlation coefficient between serum leptin levels of MZ twins was higher than that of the DZ twins. The serum level of leptin was similar between subjects with or without PCOS, irrespective of their zygosity. It was concluded that the incidence of PCOS is high among twins, and that leptin is likely to be genetically determined, although the effect of environmental factors cannot be denied. This study did not find any association between the diagnosis of PCOS and leptin level. However, the link between the two may lie with other entities such as eating disorders and/or obesity.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Iran University of Medical Science, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15497495

Citation

Jahanfar, S, et al. "Leptin and Its Association With Polycystic Ovary Syndrome: a Twin Study." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 18, no. 6, 2004, pp. 327-34.
Jahanfar S, Maleki H, Mosavi AR, et al. Leptin and its association with polycystic ovary syndrome: a twin study. Gynecol Endocrinol. 2004;18(6):327-34.
Jahanfar, S., Maleki, H., Mosavi, A. R., & Jahanfar, M. (2004). Leptin and its association with polycystic ovary syndrome: a twin study. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 18(6), pp. 327-34.
Jahanfar S, et al. Leptin and Its Association With Polycystic Ovary Syndrome: a Twin Study. Gynecol Endocrinol. 2004;18(6):327-34. PubMed PMID: 15497495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin and its association with polycystic ovary syndrome: a twin study. AU - Jahanfar,S, AU - Maleki,H, AU - Mosavi,A R, AU - Jahanfar,M, PY - 2004/10/23/pubmed PY - 2004/11/9/medline PY - 2004/10/23/entrez SP - 327 EP - 34 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 18 IS - 6 N2 - Polycystic ovary syndrome (PCOS) is a common endocrinopathy with symptoms such as obesity, insulin resistance and hyperandrogenemia. PCOS might be the result of a genetic disorder. Genetic discrepancy in the production of leptin, a product of the obesity gene, may lead to various endocrinopathies such as PCOS. The objective of this study was first, to ascertain the incidence of PCOS, using the gold standard; second, to ascertain the genetic property of leptin; and third, to evaluate the association between leptin concentration and PCOS. A total of 154 Tehran-resident female-female twins were studied. They included 48 pairs of monozygotic (MZ) and 29 pairs of dyzygotic (DZ) twins, aged 15-45 years. Clinical, ultrasound and biochemical findings were used to diagnose PCOS. The incidence of PCOS using biochemical and clinical features was 16.2%. The correlation coefficient between serum leptin levels of MZ twins was higher than that of the DZ twins. The serum level of leptin was similar between subjects with or without PCOS, irrespective of their zygosity. It was concluded that the incidence of PCOS is high among twins, and that leptin is likely to be genetically determined, although the effect of environmental factors cannot be denied. This study did not find any association between the diagnosis of PCOS and leptin level. However, the link between the two may lie with other entities such as eating disorders and/or obesity. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/15497495/Leptin_and_its_association_with_polycystic_ovary_syndrome:_a_twin_study_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -