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A novel antimicrobial indolizinium alkaloid from Aniba panurensis.
J Nat Prod. 2004 Oct; 67(10):1732-5.JN

Abstract

Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans.

Authors+Show Affiliations

Klausmeyer P
Natural Products Support Group, Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Maryland 21702-1201, USA.
Chmurny GN
No affiliation info available
McCloud TG
No affiliation info available
Tucker KD
No affiliation info available
Shoemaker RH
No affiliation info available

MeSH

Antifungal AgentsCandida albicansCryptococcus neoformansEnterococcus faeciumFluoroacetatesGuyanaIndole AlkaloidsLauraceaeMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15497951

Citation

Klausmeyer, Paul, et al. "A Novel Antimicrobial Indolizinium Alkaloid From Aniba Panurensis." Journal of Natural Products, vol. 67, no. 10, 2004, pp. 1732-5.
Klausmeyer P, Chmurny GN, McCloud TG, et al. A novel antimicrobial indolizinium alkaloid from Aniba panurensis. J Nat Prod. 2004;67(10):1732-5.
Klausmeyer, P., Chmurny, G. N., McCloud, T. G., Tucker, K. D., & Shoemaker, R. H. (2004). A novel antimicrobial indolizinium alkaloid from Aniba panurensis. Journal of Natural Products, 67(10), 1732-5.
Klausmeyer P, et al. A Novel Antimicrobial Indolizinium Alkaloid From Aniba Panurensis. J Nat Prod. 2004;67(10):1732-5. PubMed PMID: 15497951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel antimicrobial indolizinium alkaloid from Aniba panurensis. AU - Klausmeyer,Paul, AU - Chmurny,Gwendolyn N, AU - McCloud,Thomas G, AU - Tucker,Kenneth D, AU - Shoemaker,Robert H, PY - 2004/10/23/pubmed PY - 2004/12/16/medline PY - 2004/10/23/entrez SP - 1732 EP - 5 JF - Journal of natural products JO - J Nat Prod VL - 67 IS - 10 N2 - Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15497951/A_novel_antimicrobial_indolizinium_alkaloid_from_Aniba_panurensis_ DB - PRIME DP - Unbound Medicine ER -