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Viral loads in clinical specimens and SARS manifestations.
Emerg Infect Dis. 2004 Sep; 10(9):1550-7.EI

Abstract

A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

Authors+Show Affiliations

Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15498155

Citation

Hung, I F N., et al. "Viral Loads in Clinical Specimens and SARS Manifestations." Emerging Infectious Diseases, vol. 10, no. 9, 2004, pp. 1550-7.
Hung IF, Cheng VC, Wu AK, et al. Viral loads in clinical specimens and SARS manifestations. Emerging Infect Dis. 2004;10(9):1550-7.
Hung, I. F., Cheng, V. C., Wu, A. K., Tang, B. S., Chan, K. H., Chu, C. M., Wong, M. M., Hui, W. T., Poon, L. L., Tse, D. M., Chan, K. S., Woo, P. C., Lau, S. K., Peiris, J. S., & Yuen, K. Y. (2004). Viral loads in clinical specimens and SARS manifestations. Emerging Infectious Diseases, 10(9), 1550-7.
Hung IF, et al. Viral Loads in Clinical Specimens and SARS Manifestations. Emerging Infect Dis. 2004;10(9):1550-7. PubMed PMID: 15498155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viral loads in clinical specimens and SARS manifestations. AU - Hung,I F N, AU - Cheng,V C C, AU - Wu,A K L, AU - Tang,B S F, AU - Chan,K H, AU - Chu,C M, AU - Wong,M M L, AU - Hui,W T, AU - Poon,L L M, AU - Tse,D M W, AU - Chan,K S, AU - Woo,P C Y, AU - Lau,S K P, AU - Peiris,J S M, AU - Yuen,K Y, PY - 2004/10/23/pubmed PY - 2004/12/16/medline PY - 2004/10/23/entrez SP - 1550 EP - 7 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 10 IS - 9 N2 - A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS. SN - 1080-6040 UR - https://www.unboundmedicine.com/medline/citation/15498155/full_citation L2 - https://www.cdc.gov/ncidod/EID/vol10no9/04-0058.htm DB - PRIME DP - Unbound Medicine ER -