TY - JOUR T1 - Viral loads in clinical specimens and SARS manifestations. AU - Hung,I F N, AU - Cheng,V C C, AU - Wu,A K L, AU - Tang,B S F, AU - Chan,K H, AU - Chu,C M, AU - Wong,M M L, AU - Hui,W T, AU - Poon,L L M, AU - Tse,D M W, AU - Chan,K S, AU - Woo,P C Y, AU - Lau,S K P, AU - Peiris,J S M, AU - Yuen,K Y, PY - 2004/10/23/pubmed PY - 2004/12/16/medline PY - 2004/10/23/entrez SP - 1550 EP - 7 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 10 IS - 9 N2 - A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS. SN - 1080-6040 UR - https://www.unboundmedicine.com/medline/citation/15498155/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/15498155/ DB - PRIME DP - Unbound Medicine ER -