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Viral loads in clinical specimens and SARS manifestations.
Emerg Infect Dis. 2004 Sep; 10(9):1550-7.EI

Abstract

A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.

Links

Publisher Full Text
ncbi.nlm.nih.gov
cdc.gov
PMC Free PDF

Authors+Show Affiliations

Hung IF
Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.
Cheng VC
No affiliation info available
Wu AK
No affiliation info available
Tang BS
No affiliation info available
Chan KH
No affiliation info available
Chu CM
No affiliation info available
Wong MM
No affiliation info available
Hui WT
No affiliation info available
Poon LL
No affiliation info available
Tse DM
No affiliation info available
Chan KS
No affiliation info available
Woo PC
No affiliation info available
Lau SK
No affiliation info available
Peiris JS
No affiliation info available
Yuen KY
No affiliation info available

MeSH

AdultAgedAged, 80 and overDisease OutbreaksFecesFemaleHumansMaleMiddle AgedNasopharynxSARS VirusSevere Acute Respiratory SyndromeViral Load

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15498155

Citation

Hung, I F N., et al. "Viral Loads in Clinical Specimens and SARS Manifestations." Emerging Infectious Diseases, vol. 10, no. 9, 2004, pp. 1550-7.
Hung IF, Cheng VC, Wu AK, et al. Viral loads in clinical specimens and SARS manifestations. Emerging Infect Dis. 2004;10(9):1550-7.
Hung, I. F., Cheng, V. C., Wu, A. K., Tang, B. S., Chan, K. H., Chu, C. M., Wong, M. M., Hui, W. T., Poon, L. L., Tse, D. M., Chan, K. S., Woo, P. C., Lau, S. K., Peiris, J. S., & Yuen, K. Y. (2004). Viral loads in clinical specimens and SARS manifestations. Emerging Infectious Diseases, 10(9), 1550-7.
Hung IF, et al. Viral Loads in Clinical Specimens and SARS Manifestations. Emerging Infect Dis. 2004;10(9):1550-7. PubMed PMID: 15498155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viral loads in clinical specimens and SARS manifestations. AU - Hung,I F N, AU - Cheng,V C C, AU - Wu,A K L, AU - Tang,B S F, AU - Chan,K H, AU - Chu,C M, AU - Wong,M M L, AU - Hui,W T, AU - Poon,L L M, AU - Tse,D M W, AU - Chan,K S, AU - Woo,P C Y, AU - Lau,S K P, AU - Peiris,J S M, AU - Yuen,K Y, PY - 2004/10/23/pubmed PY - 2004/12/16/medline PY - 2004/10/23/entrez SP - 1550 EP - 7 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 10 IS - 9 N2 - A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS. SN - 1080-6040 UR - https://www.unboundmedicine.com/medline/citation/15498155/full_citation L2 - https://www.cdc.gov/ncidod/EID/vol10no9/04-0058.htm DB - PRIME DP - Unbound Medicine ER -