Tags

Type your tag names separated by a space and hit enter

Dose and behavioral context dependent inhibition of movement and basal ganglia neural activity by Delta-9-tetrahydrocannabinol during spontaneous and treadmill locomotion tasks in rats.
Synapse 2005; 55(1):1-16S

Abstract

The effects of Delta-9-tetrahydrocannabinole (Delta-9-THC) on locomotor activities and related basal ganglia neural responses were investigated in rats. A multiple-channel, single unit recording method was used to record neuronal activity in the dorsal lateral striatum, the globus pallidus, the subthalamic nucleus, and the substantia nigra pars reticulata simultaneously during spontaneous movement and treadmill locomotion. Delta-9-THC treatment (0.05-2.0 mg/kg, i.p.) dose-dependently decreased spontaneous motor activity and altered walking patterns in treadmill locomotion in that stance time was increased and step number was decreased. In parallel with the behavioral effects, Delta-9-THC treatment inhibited neural activity across all four basal ganglia areas recorded during both motor tests. Further, this inhibition of basal ganglia neural activity was behavioral context-dependent. Greater inhibition was found during resting than during walking periods in the treadmill locomotion test. Delta-9-THC treatment also changed firing patterns in the striatum and globus pallidus. More neurons in these regions discharged in an oscillatory pattern during treadmill walking with Delta-9-THC, and the oscillatory frequency was similar to that of the step cycle. Synchronized firing patterns were found in few basal ganglia neurons in the control condition (approximately 1%). Synchronized firing patterns increased during the treadmill resting phase after Delta-9-THC treatment, but still represented a very small proportion of the total neural population (1.9%). The drug treatment did not change neural responses to the tone cue proceeding treadmill locomotion. This study demonstrates dose-dependent inhibitory effects of cannabinoid injection on motor activity. This effect may be related to the behavioral context-dependent inhibition observed in the basal ganglia system where CB1 receptors are densely distributed.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, North Carolina 27157, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15499609

Citation

Shi, L H., et al. "Dose and Behavioral Context Dependent Inhibition of Movement and Basal Ganglia Neural Activity By Delta-9-tetrahydrocannabinol During Spontaneous and Treadmill Locomotion Tasks in Rats." Synapse (New York, N.Y.), vol. 55, no. 1, 2005, pp. 1-16.
Shi LH, Luo F, Woodward DJ, et al. Dose and behavioral context dependent inhibition of movement and basal ganglia neural activity by Delta-9-tetrahydrocannabinol during spontaneous and treadmill locomotion tasks in rats. Synapse. 2005;55(1):1-16.
Shi, L. H., Luo, F., Woodward, D. J., & Chang, J. Y. (2005). Dose and behavioral context dependent inhibition of movement and basal ganglia neural activity by Delta-9-tetrahydrocannabinol during spontaneous and treadmill locomotion tasks in rats. Synapse (New York, N.Y.), 55(1), pp. 1-16.
Shi LH, et al. Dose and Behavioral Context Dependent Inhibition of Movement and Basal Ganglia Neural Activity By Delta-9-tetrahydrocannabinol During Spontaneous and Treadmill Locomotion Tasks in Rats. Synapse. 2005;55(1):1-16. PubMed PMID: 15499609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose and behavioral context dependent inhibition of movement and basal ganglia neural activity by Delta-9-tetrahydrocannabinol during spontaneous and treadmill locomotion tasks in rats. AU - Shi,L H, AU - Luo,F, AU - Woodward,D J, AU - Chang,J Y, PY - 2004/10/23/pubmed PY - 2005/2/18/medline PY - 2004/10/23/entrez SP - 1 EP - 16 JF - Synapse (New York, N.Y.) JO - Synapse VL - 55 IS - 1 N2 - The effects of Delta-9-tetrahydrocannabinole (Delta-9-THC) on locomotor activities and related basal ganglia neural responses were investigated in rats. A multiple-channel, single unit recording method was used to record neuronal activity in the dorsal lateral striatum, the globus pallidus, the subthalamic nucleus, and the substantia nigra pars reticulata simultaneously during spontaneous movement and treadmill locomotion. Delta-9-THC treatment (0.05-2.0 mg/kg, i.p.) dose-dependently decreased spontaneous motor activity and altered walking patterns in treadmill locomotion in that stance time was increased and step number was decreased. In parallel with the behavioral effects, Delta-9-THC treatment inhibited neural activity across all four basal ganglia areas recorded during both motor tests. Further, this inhibition of basal ganglia neural activity was behavioral context-dependent. Greater inhibition was found during resting than during walking periods in the treadmill locomotion test. Delta-9-THC treatment also changed firing patterns in the striatum and globus pallidus. More neurons in these regions discharged in an oscillatory pattern during treadmill walking with Delta-9-THC, and the oscillatory frequency was similar to that of the step cycle. Synchronized firing patterns were found in few basal ganglia neurons in the control condition (approximately 1%). Synchronized firing patterns increased during the treadmill resting phase after Delta-9-THC treatment, but still represented a very small proportion of the total neural population (1.9%). The drug treatment did not change neural responses to the tone cue proceeding treadmill locomotion. This study demonstrates dose-dependent inhibitory effects of cannabinoid injection on motor activity. This effect may be related to the behavioral context-dependent inhibition observed in the basal ganglia system where CB1 receptors are densely distributed. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/15499609/Dose_and_behavioral_context_dependent_inhibition_of_movement_and_basal_ganglia_neural_activity_by_Delta_9_tetrahydrocannabinol_during_spontaneous_and_treadmill_locomotion_tasks_in_rats_ L2 - https://doi.org/10.1002/syn.20088 DB - PRIME DP - Unbound Medicine ER -