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Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study.
Phytomedicine 2004; 11(6):470-7P

Abstract

Comfrey (Symphytum officinale L.) is a medicinal plant with anti-inflammatory, analgesic and tissue regenerating properties. In a double-blind, multicenter, randomized, placebo-controlled, group comparison study on patients suffering from unilateral acute ankle sprains (n = 142, mean age 31.8 years, 78.9% male), the percutaneous efficacy of an ointment of comfrey extract (Kytta-Salbe f, four treatments per day for 8 days) was confirmed decisively. Compared to placebo, the active treatment was clearly superior regarding the reduction of pain (tonometric measurement, p<0.0001, as the primary efficacy variable) and ankle edema (figure-of-eight method, p = 0.0001). Statistically significant differences between active treatment and placebo could also be shown for ankle mobility (neutral zero method), and global efficacy. Under active treatment, no adverse drug reactions were reported. The good local and global tolerance of the trial medication could also be confirmed. The study results are consistent with the known pre-clinical and clinical data concerning comfrey.

Authors+Show Affiliations

Merck Selbstmedikation GmbH, Roesslerstr. 96, D-64293 Darmstadt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

15500257

Citation

Koll, R, et al. "Efficacy and Tolerance of a Comfrey Root Extract (Extr. Rad. Symphyti) in the Treatment of Ankle Distorsions: Results of a Multicenter, Randomized, Placebo-controlled, Double-blind Study." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 11, no. 6, 2004, pp. 470-7.
Koll R, Buhr M, Dieter R, et al. Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine. 2004;11(6):470-7.
Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., ... Staiger, C. (2004). Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 11(6), pp. 470-7.
Koll R, et al. Efficacy and Tolerance of a Comfrey Root Extract (Extr. Rad. Symphyti) in the Treatment of Ankle Distorsions: Results of a Multicenter, Randomized, Placebo-controlled, Double-blind Study. Phytomedicine. 2004;11(6):470-7. PubMed PMID: 15500257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. AU - Koll,R, AU - Buhr,M, AU - Dieter,R, AU - Pabst,H, AU - Predel,H G, AU - Petrowicz,O, AU - Giannetti,B, AU - Klingenburg,S, AU - Staiger,C, PY - 2004/10/27/pubmed PY - 2004/12/16/medline PY - 2004/10/27/entrez SP - 470 EP - 7 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 11 IS - 6 N2 - Comfrey (Symphytum officinale L.) is a medicinal plant with anti-inflammatory, analgesic and tissue regenerating properties. In a double-blind, multicenter, randomized, placebo-controlled, group comparison study on patients suffering from unilateral acute ankle sprains (n = 142, mean age 31.8 years, 78.9% male), the percutaneous efficacy of an ointment of comfrey extract (Kytta-Salbe f, four treatments per day for 8 days) was confirmed decisively. Compared to placebo, the active treatment was clearly superior regarding the reduction of pain (tonometric measurement, p<0.0001, as the primary efficacy variable) and ankle edema (figure-of-eight method, p = 0.0001). Statistically significant differences between active treatment and placebo could also be shown for ankle mobility (neutral zero method), and global efficacy. Under active treatment, no adverse drug reactions were reported. The good local and global tolerance of the trial medication could also be confirmed. The study results are consistent with the known pre-clinical and clinical data concerning comfrey. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/15500257/Efficacy_and_tolerance_of_a_comfrey_root_extract__Extr__Rad__Symphyti__in_the_treatment_of_ankle_distorsions:_results_of_a_multicenter_randomized_placebo_controlled_double_blind_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(04)00032-7 DB - PRIME DP - Unbound Medicine ER -