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Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study.

Abstract

Comfrey (Symphytum officinale L.) is a medicinal plant with anti-inflammatory, analgesic and tissue regenerating properties. In a double-blind, multicenter, randomized, placebo-controlled, group comparison study on patients suffering from unilateral acute ankle sprains (n = 142, mean age 31.8 years, 78.9% male), the percutaneous efficacy of an ointment of comfrey extract (Kytta-Salbe f, four treatments per day for 8 days) was confirmed decisively. Compared to placebo, the active treatment was clearly superior regarding the reduction of pain (tonometric measurement, p<0.0001, as the primary efficacy variable) and ankle edema (figure-of-eight method, p = 0.0001). Statistically significant differences between active treatment and placebo could also be shown for ankle mobility (neutral zero method), and global efficacy. Under active treatment, no adverse drug reactions were reported. The good local and global tolerance of the trial medication could also be confirmed. The study results are consistent with the known pre-clinical and clinical data concerning comfrey.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Merck Selbstmedikation GmbH, Roesslerstr. 96, D-64293 Darmstadt, Germany.

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Ankle Injuries
    Comfrey
    Double-Blind Method
    Female
    Germany
    Humans
    Male
    Middle Aged
    Pain
    Phytotherapy
    Plant Extracts
    Plant Roots
    Sprains and Strains
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    15500257

    Citation

    Koll, R, et al. "Efficacy and Tolerance of a Comfrey Root Extract (Extr. Rad. Symphyti) in the Treatment of Ankle Distorsions: Results of a Multicenter, Randomized, Placebo-controlled, Double-blind Study." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 11, no. 6, 2004, pp. 470-7.
    Koll R, Buhr M, Dieter R, et al. Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine. 2004;11(6):470-7.
    Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., ... Staiger, C. (2004). Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 11(6), pp. 470-7.
    Koll R, et al. Efficacy and Tolerance of a Comfrey Root Extract (Extr. Rad. Symphyti) in the Treatment of Ankle Distorsions: Results of a Multicenter, Randomized, Placebo-controlled, Double-blind Study. Phytomedicine. 2004;11(6):470-7. PubMed PMID: 15500257.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. AU - Koll,R, AU - Buhr,M, AU - Dieter,R, AU - Pabst,H, AU - Predel,H G, AU - Petrowicz,O, AU - Giannetti,B, AU - Klingenburg,S, AU - Staiger,C, PY - 2004/10/27/pubmed PY - 2004/12/16/medline PY - 2004/10/27/entrez SP - 470 EP - 7 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 11 IS - 6 N2 - Comfrey (Symphytum officinale L.) is a medicinal plant with anti-inflammatory, analgesic and tissue regenerating properties. In a double-blind, multicenter, randomized, placebo-controlled, group comparison study on patients suffering from unilateral acute ankle sprains (n = 142, mean age 31.8 years, 78.9% male), the percutaneous efficacy of an ointment of comfrey extract (Kytta-Salbe f, four treatments per day for 8 days) was confirmed decisively. Compared to placebo, the active treatment was clearly superior regarding the reduction of pain (tonometric measurement, p<0.0001, as the primary efficacy variable) and ankle edema (figure-of-eight method, p = 0.0001). Statistically significant differences between active treatment and placebo could also be shown for ankle mobility (neutral zero method), and global efficacy. Under active treatment, no adverse drug reactions were reported. The good local and global tolerance of the trial medication could also be confirmed. The study results are consistent with the known pre-clinical and clinical data concerning comfrey. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/15500257/Efficacy_and_tolerance_of_a_comfrey_root_extract__Extr__Rad__Symphyti__in_the_treatment_of_ankle_distorsions:_results_of_a_multicenter_randomized_placebo_controlled_double_blind_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(04)00032-7 DB - PRIME DP - Unbound Medicine ER -