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Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction.
Food Chem Toxicol. 2004 Dec; 42(12):2053-60.FC

Abstract

The present study was carried out to investigate the effects of copper (Cu) intake on lipid profile, oxidative stress and tissue damage in normal and in diabetic condition. Since diabetes mellitus is a situation of high-risk susceptibility to toxic compounds, we examined potential early markers of Cu excess in diabetic animals. Male Wistar rats, at 60-days-old were divided into six groups of eight rats each. The control(C) received saline from gastric tube, the no-diabetic(Cu-10), treated with 10 mg/kg of Cu(Cu(++)-CuSO4, gastric tube), no-diabetic with Cu-60 mg/kg(Cu-60), diabetic(D), diabetic low-Cu(DCu-10) and diabetic high-Cu(DCu-60). Diabetes was induced by an ip injection of streptozotocin (60 mg/kg). After 30 days of treatments, no changes were observed in serum lactate dehydrogenase, alanine transaminase and alkaline phosphatase, indicating no adverse effects on cardiac and hepatic tissues. D-rats had glucose intolerance and dyslipidemic profile. Cholesterol and LDL-cholesterol were higher in Cu-60 and DCu-60 than in C, Cu-10 and D and DCu-10 groups respectively. Cu-60 rats had higher lipid hydroperoxide (HP) and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) serum activities than C and Cu-10 rats. LH was increased and GSH-Px was decreased, while no alterations were observed in SOD and catalase in serum of DCu-60 animals. DCu-60 rats had increased urinary glucose, creatinine and albumin. In conclusion, Cu intake at high concentration induced adverse effects on lipid profile, associated with oxidative stress and diminished activities of antioxidant enzymes. Diabetic animals were more susceptible to copper toxicity. High Cu intake induced dyslipidemic profile, oxidative stress and kidney dysfunction in diabetic condition. Copper renal toxicity was associated with oxidative stress and reduction at least, one of the antioxidant enzymes.

Authors+Show Affiliations

Galhardi CM
Department of Chemistry and Biochemistry, Institute of Biological Sciences, University Estadual Paulista-UNESP, Botucatu, São Paulo, Brazil.
Diniz YS
No affiliation info available
Faine LA
No affiliation info available
Rodrigues HG
No affiliation info available
Burneiko RC
No affiliation info available
Ribas BO
No affiliation info available
Novelli EL
No affiliation info available

MeSH

AnimalsBlood GlucoseBody WeightCopperDiabetes Mellitus, ExperimentalEatingGlucose Tolerance TestKidney DiseasesLipid PeroxidationLipidsMaleOxidative StressRatsRats, WistarWeight Gain

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15500942

Citation

Galhardi, Cristiano M., et al. "Toxicity of Copper Intake: Lipid Profile, Oxidative Stress and Susceptibility to Renal Dysfunction." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 42, no. 12, 2004, pp. 2053-60.
Galhardi CM, Diniz YS, Faine LA, et al. Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food Chem Toxicol. 2004;42(12):2053-60.
Galhardi, C. M., Diniz, Y. S., Faine, L. A., Rodrigues, H. G., Burneiko, R. C., Ribas, B. O., & Novelli, E. L. (2004). Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 42(12), 2053-60.
Galhardi CM, et al. Toxicity of Copper Intake: Lipid Profile, Oxidative Stress and Susceptibility to Renal Dysfunction. Food Chem Toxicol. 2004;42(12):2053-60. PubMed PMID: 15500942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. AU - Galhardi,Cristiano M, AU - Diniz,Yeda S, AU - Faine,Luciane A, AU - Rodrigues,Hosana G, AU - Burneiko,Regina C M, AU - Ribas,Bartolome O, AU - Novelli,Ethel L B, PY - 2004/01/09/received PY - 2004/07/29/accepted PY - 2004/10/27/pubmed PY - 2004/12/21/medline PY - 2004/10/27/entrez SP - 2053 EP - 60 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 42 IS - 12 N2 - The present study was carried out to investigate the effects of copper (Cu) intake on lipid profile, oxidative stress and tissue damage in normal and in diabetic condition. Since diabetes mellitus is a situation of high-risk susceptibility to toxic compounds, we examined potential early markers of Cu excess in diabetic animals. Male Wistar rats, at 60-days-old were divided into six groups of eight rats each. The control(C) received saline from gastric tube, the no-diabetic(Cu-10), treated with 10 mg/kg of Cu(Cu(++)-CuSO4, gastric tube), no-diabetic with Cu-60 mg/kg(Cu-60), diabetic(D), diabetic low-Cu(DCu-10) and diabetic high-Cu(DCu-60). Diabetes was induced by an ip injection of streptozotocin (60 mg/kg). After 30 days of treatments, no changes were observed in serum lactate dehydrogenase, alanine transaminase and alkaline phosphatase, indicating no adverse effects on cardiac and hepatic tissues. D-rats had glucose intolerance and dyslipidemic profile. Cholesterol and LDL-cholesterol were higher in Cu-60 and DCu-60 than in C, Cu-10 and D and DCu-10 groups respectively. Cu-60 rats had higher lipid hydroperoxide (HP) and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) serum activities than C and Cu-10 rats. LH was increased and GSH-Px was decreased, while no alterations were observed in SOD and catalase in serum of DCu-60 animals. DCu-60 rats had increased urinary glucose, creatinine and albumin. In conclusion, Cu intake at high concentration induced adverse effects on lipid profile, associated with oxidative stress and diminished activities of antioxidant enzymes. Diabetic animals were more susceptible to copper toxicity. High Cu intake induced dyslipidemic profile, oxidative stress and kidney dysfunction in diabetic condition. Copper renal toxicity was associated with oxidative stress and reduction at least, one of the antioxidant enzymes. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/15500942/Toxicity_of_copper_intake:_lipid_profile_oxidative_stress_and_susceptibility_to_renal_dysfunction_ DB - PRIME DP - Unbound Medicine ER -