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Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats.
Pharmacol Biochem Behav 2004; 79(2):331-42PB

Abstract

The current experiment investigated the effect of 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') preexposure on the acquisition of intravenous amphetamine self-administration and the reinstatement of amphetamine-seeking behavior by either MDMA or amphetamine. Rats were preexposed to a 5-HT depleting regime of MDMA (5 mg/kg every hour for 4 h on two consecutive days) or equivalent vehicle injections. Intravenous self-administration of low dose d-amphetamine (0.03 mg/kg/infusion) on a FR1 schedule was subsequently assessed. The rats were then given 2 weeks of extinction and tested for drug-seeking behavior with priming doses of amphetamine or MDMA. Brains were analysed for monoamine content using high-performance liquid chromatography (HPLC). MDMA-preexposed rats were initially slower to acquire amphetamine self-administration. However, by day 6 of acquisition, there was no difference from controls. Following extinction, amphetamine (1 mg/kg, i.p.) reinstated drug seeking and produced locomotor hyperactivity in both MDMA- and vehicle-pretreated animals. However, MDMA (5 mg/kg, i.p.) was only effective in producing amphetamine seeking and hyperactivity in MDMA-pretreated rats. MDMA pretreatment caused significant decreases in 5-hydroxy-indolacetic acid (5-HIAA) and 5-HT in several brain regions. These results suggest that 5-HT depletion induced by MDMA may initially slow the acquisition of amphetamine self-administration but that MDMA preexposure may also sensitize animals to the locomotor stimulating and priming effects of MDMA on drug-seeking behavior.

Authors+Show Affiliations

School of Psychology, University of Sydney, NSW 2006, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15501310

Citation

Morley, Kirsten C., et al. "Preexposure to MDMA ("Ecstasy") Delays Acquisition but Facilitates MDMA-induced Reinstatement of Amphetamine Self-administration Behavior in Rats." Pharmacology, Biochemistry, and Behavior, vol. 79, no. 2, 2004, pp. 331-42.
Morley KC, Cornish JL, Li KM, et al. Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats. Pharmacol Biochem Behav. 2004;79(2):331-42.
Morley, K. C., Cornish, J. L., Li, K. M., & McGregor, I. S. (2004). Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats. Pharmacology, Biochemistry, and Behavior, 79(2), pp. 331-42.
Morley KC, et al. Preexposure to MDMA ("Ecstasy") Delays Acquisition but Facilitates MDMA-induced Reinstatement of Amphetamine Self-administration Behavior in Rats. Pharmacol Biochem Behav. 2004;79(2):331-42. PubMed PMID: 15501310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats. AU - Morley,Kirsten C, AU - Cornish,Jennifer L, AU - Li,Kong M, AU - McGregor,Iain S, PY - 2004/01/23/received PY - 2004/08/06/revised PY - 2004/08/09/accepted PY - 2004/10/27/pubmed PY - 2005/4/20/medline PY - 2004/10/27/entrez SP - 331 EP - 42 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 79 IS - 2 N2 - The current experiment investigated the effect of 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') preexposure on the acquisition of intravenous amphetamine self-administration and the reinstatement of amphetamine-seeking behavior by either MDMA or amphetamine. Rats were preexposed to a 5-HT depleting regime of MDMA (5 mg/kg every hour for 4 h on two consecutive days) or equivalent vehicle injections. Intravenous self-administration of low dose d-amphetamine (0.03 mg/kg/infusion) on a FR1 schedule was subsequently assessed. The rats were then given 2 weeks of extinction and tested for drug-seeking behavior with priming doses of amphetamine or MDMA. Brains were analysed for monoamine content using high-performance liquid chromatography (HPLC). MDMA-preexposed rats were initially slower to acquire amphetamine self-administration. However, by day 6 of acquisition, there was no difference from controls. Following extinction, amphetamine (1 mg/kg, i.p.) reinstated drug seeking and produced locomotor hyperactivity in both MDMA- and vehicle-pretreated animals. However, MDMA (5 mg/kg, i.p.) was only effective in producing amphetamine seeking and hyperactivity in MDMA-pretreated rats. MDMA pretreatment caused significant decreases in 5-hydroxy-indolacetic acid (5-HIAA) and 5-HT in several brain regions. These results suggest that 5-HT depletion induced by MDMA may initially slow the acquisition of amphetamine self-administration but that MDMA preexposure may also sensitize animals to the locomotor stimulating and priming effects of MDMA on drug-seeking behavior. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/15501310/Preexposure_to_MDMA__"Ecstasy"__delays_acquisition_but_facilitates_MDMA_induced_reinstatement_of_amphetamine_self_administration_behavior_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(04)00253-9 DB - PRIME DP - Unbound Medicine ER -