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The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control.
Diabetologia. 2004 Oct; 47(10):1838-46.D

Abstract

AIMS/HYPOTHESIS

The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the postprandial state.

METHODS

We studied 19 postmenopausal women with type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting state, and again 3 hours after a mixed meal (660 kcal, 55% fat).

RESULTS

Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA1c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group.

CONCLUSIONS/INTERPRETATION

The postprandial state does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with type 2 diabetes, irrespective of glycaemic control.

Authors+Show Affiliations

Lipid and Diabetes Research Group, Hagley Building, Christchurch Hospital, Christchurch, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15502920

Citation

Strey, C H., et al. "The Postprandial State Does Not Impair Endothelial Function in Women With Type 2 Diabetes Irrespective of Glycaemic Control." Diabetologia, vol. 47, no. 10, 2004, pp. 1838-46.
Strey CH, Young J, Collier M, et al. The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control. Diabetologia. 2004;47(10):1838-46.
Strey, C. H., Young, J., Collier, M., Florkowski, C. M., Shand, B. I., & Scott, R. S. (2004). The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control. Diabetologia, 47(10), 1838-46.
Strey CH, et al. The Postprandial State Does Not Impair Endothelial Function in Women With Type 2 Diabetes Irrespective of Glycaemic Control. Diabetologia. 2004;47(10):1838-46. PubMed PMID: 15502920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The postprandial state does not impair endothelial function in women with type 2 diabetes irrespective of glycaemic control. AU - Strey,C H, AU - Young,J, AU - Collier,M, AU - Florkowski,C M, AU - Shand,B I, AU - Scott,R S, Y1 - 2004/10/22/ PY - 2004/03/15/received PY - 2004/06/10/accepted PY - 2004/10/27/pubmed PY - 2005/4/15/medline PY - 2004/10/27/entrez SP - 1838 EP - 46 JF - Diabetologia JO - Diabetologia VL - 47 IS - 10 N2 - AIMS/HYPOTHESIS: The postprandial state has been shown to be associated with endothelial dysfunction, a predictor of cardiovascular morbidity. In type 2 diabetes, postprandial metabolic excursions are prolonged and exaggerated, but less pronounced if glycaemic control is optimised. We investigated the impact of improved glycaemic control on endothelial function in the postprandial state. METHODS: We studied 19 postmenopausal women with type 2 diabetes and ten non-diabetic subjects. Participants with diabetes were re-studied 3 months after intensive glucose regulation. We measured forearm blood flow by strain gauge plethysmography during rest, during acetylcholine infusion and post ischaemia in the fasting state, and again 3 hours after a mixed meal (660 kcal, 55% fat). RESULTS: Endothelium-dependent vasodilation was impaired in the diabetic group (p<0.005) and improved following an HbA1c reduction of 0.96% (p<0.05 for high-dose acetylcholine infusion). Postprandial metabolic excursions were higher in the diabetic group (p<0.001, p<0.01 and p<0.05 for glucose, insulin and triglycerides respectively). Resting forearm blood flow increased in all groups after the meal (p<0.005). There was no difference in fasting and postprandial endothelium-dependent vasodilation before and after improved glucose regulation in either group. CONCLUSIONS/INTERPRETATION: The postprandial state does not impair endothelial function in non-diabetic women and does not make pre-existing endothelial dysfunction worse in women with type 2 diabetes, irrespective of glycaemic control. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/15502920/The_postprandial_state_does_not_impair_endothelial_function_in_women_with_type_2_diabetes_irrespective_of_glycaemic_control_ L2 - https://doi.org/10.1007/s00125-004-1534-0 DB - PRIME DP - Unbound Medicine ER -