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Opioids in renal failure and dialysis patients.
J Pain Symptom Manage. 2004 Nov; 28(5):497-504.JP

Abstract

This article reviews the literature pertaining to the metabolism of several of the commonly used opioids, and the known activity of their metabolites. The effect of renal failure on the pharmacokinetics of these drugs and metabolites is then reviewed. Finally, the effect of renal dialysis on opioid drugs and metabolites is reviewed. Based on the review, it is recommended that morphine and codeine are avoided in renal failure/dialysis patients; hydromorphone or oxycodone are used with caution and close monitoring; and that methadone and fentanyl/sufentanil appear to be safe to use. Note is made that the "safe" drugs in renal failure are also the least dialyzable.

Authors+Show Affiliations

Palliative Care Department, Western Memorial Regional Hospital, Corner Brook, Newfoundland and Labrador, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15504625

Citation

Dean, Mervyn. "Opioids in Renal Failure and Dialysis Patients." Journal of Pain and Symptom Management, vol. 28, no. 5, 2004, pp. 497-504.
Dean M. Opioids in renal failure and dialysis patients. J Pain Symptom Manage. 2004;28(5):497-504.
Dean, M. (2004). Opioids in renal failure and dialysis patients. Journal of Pain and Symptom Management, 28(5), 497-504.
Dean M. Opioids in Renal Failure and Dialysis Patients. J Pain Symptom Manage. 2004;28(5):497-504. PubMed PMID: 15504625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioids in renal failure and dialysis patients. A1 - Dean,Mervyn, PY - 2004/02/20/accepted PY - 2004/10/27/pubmed PY - 2005/1/6/medline PY - 2004/10/27/entrez SP - 497 EP - 504 JF - Journal of pain and symptom management JO - J Pain Symptom Manage VL - 28 IS - 5 N2 - This article reviews the literature pertaining to the metabolism of several of the commonly used opioids, and the known activity of their metabolites. The effect of renal failure on the pharmacokinetics of these drugs and metabolites is then reviewed. Finally, the effect of renal dialysis on opioid drugs and metabolites is reviewed. Based on the review, it is recommended that morphine and codeine are avoided in renal failure/dialysis patients; hydromorphone or oxycodone are used with caution and close monitoring; and that methadone and fentanyl/sufentanil appear to be safe to use. Note is made that the "safe" drugs in renal failure are also the least dialyzable. SN - 0885-3924 UR - https://www.unboundmedicine.com/medline/citation/15504625/Opioids_in_renal_failure_and_dialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0885-3924(04)00335-5 DB - PRIME DP - Unbound Medicine ER -
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