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Postprandial glucose regulation and diabetic complications.
Arch Intern Med. 2004 Oct 25; 164(19):2090-5.AI

Abstract

Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA(1c)) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA(1c) level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes.

Authors+Show Affiliations

Department of Pathology and Medicine Experimental and Clinical, University of Udine, Udine, Italy. ceriello@uniuid.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15505121

Citation

Ceriello, Antonio, et al. "Postprandial Glucose Regulation and Diabetic Complications." Archives of Internal Medicine, vol. 164, no. 19, 2004, pp. 2090-5.
Ceriello A, Hanefeld M, Leiter L, et al. Postprandial glucose regulation and diabetic complications. Arch Intern Med. 2004;164(19):2090-5.
Ceriello, A., Hanefeld, M., Leiter, L., Monnier, L., Moses, A., Owens, D., Tajima, N., & Tuomilehto, J. (2004). Postprandial glucose regulation and diabetic complications. Archives of Internal Medicine, 164(19), 2090-5.
Ceriello A, et al. Postprandial Glucose Regulation and Diabetic Complications. Arch Intern Med. 2004 Oct 25;164(19):2090-5. PubMed PMID: 15505121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial glucose regulation and diabetic complications. AU - Ceriello,Antonio, AU - Hanefeld,Markolf, AU - Leiter,Lawrence, AU - Monnier,Louis, AU - Moses,Alan, AU - Owens,David, AU - Tajima,Naoko, AU - Tuomilehto,Jaakko, PY - 2004/10/27/pubmed PY - 2005/4/13/medline PY - 2004/10/27/entrez SP - 2090 EP - 5 JF - Archives of internal medicine JO - Arch Intern Med VL - 164 IS - 19 N2 - Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA(1c)) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA(1c) level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15505121/Postprandial_glucose_regulation_and_diabetic_complications_ DB - PRIME DP - Unbound Medicine ER -