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Effects of pyridostigmine bromide on physiological responses to heat, exercise, and hypohydration.
Aviat Space Environ Med. 1992 Jan; 63(1):37-45.AS

Abstract

Five men underwent eight heat stress tests (HSTs) at 35 degrees C, each consisting of four 25-min treadmill walks (35% Vo2max), separated by 5-min rests, in four conditions: 1) 20% relative humidity (rh), subjects euhydrated and drinking ad libitum; 2) 20% rh, euhydrated; 3) 75% rh, euhydrated; and 4) 20% rh, hypohydrated 3% of body weight. In Conditions 2-4 subjects drank during the walks to maintain their pre-HST weight. In each condition we tested subjects once after 30 mg pyridostigmine bromide (PB) by mouth and once after placebo. PB lowered heart rate a mean of 3 beats/min overall, most with hypohydration. PB did not significantly affect rectal temperature (Tre), but reduced the rise in Tre during hypohydrated exercise. In Condition 2, chest skin temperature decreased more during exercise with PB. PB had no significant effect on other skin temperatures, sweating, hematocrit, hemoglobin, total plasma protein, osmolality, ad libitum drinking, rate of O2 uptake, or subject ratings of temperature, discomfort, or exertion. PB thus had little effect on physiological responses to moderate exercise-heat stress.

Authors+Show Affiliations

U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-4837.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1550532

Citation

Wenger, C B., and W A. Latzka. "Effects of Pyridostigmine Bromide On Physiological Responses to Heat, Exercise, and Hypohydration." Aviation, Space, and Environmental Medicine, vol. 63, no. 1, 1992, pp. 37-45.
Wenger CB, Latzka WA. Effects of pyridostigmine bromide on physiological responses to heat, exercise, and hypohydration. Aviat Space Environ Med. 1992;63(1):37-45.
Wenger, C. B., & Latzka, W. A. (1992). Effects of pyridostigmine bromide on physiological responses to heat, exercise, and hypohydration. Aviation, Space, and Environmental Medicine, 63(1), 37-45.
Wenger CB, Latzka WA. Effects of Pyridostigmine Bromide On Physiological Responses to Heat, Exercise, and Hypohydration. Aviat Space Environ Med. 1992;63(1):37-45. PubMed PMID: 1550532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pyridostigmine bromide on physiological responses to heat, exercise, and hypohydration. AU - Wenger,C B, AU - Latzka,W A, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 37 EP - 45 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 63 IS - 1 N2 - Five men underwent eight heat stress tests (HSTs) at 35 degrees C, each consisting of four 25-min treadmill walks (35% Vo2max), separated by 5-min rests, in four conditions: 1) 20% relative humidity (rh), subjects euhydrated and drinking ad libitum; 2) 20% rh, euhydrated; 3) 75% rh, euhydrated; and 4) 20% rh, hypohydrated 3% of body weight. In Conditions 2-4 subjects drank during the walks to maintain their pre-HST weight. In each condition we tested subjects once after 30 mg pyridostigmine bromide (PB) by mouth and once after placebo. PB lowered heart rate a mean of 3 beats/min overall, most with hypohydration. PB did not significantly affect rectal temperature (Tre), but reduced the rise in Tre during hypohydrated exercise. In Condition 2, chest skin temperature decreased more during exercise with PB. PB had no significant effect on other skin temperatures, sweating, hematocrit, hemoglobin, total plasma protein, osmolality, ad libitum drinking, rate of O2 uptake, or subject ratings of temperature, discomfort, or exertion. PB thus had little effect on physiological responses to moderate exercise-heat stress. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/1550532/Effects_of_pyridostigmine_bromide_on_physiological_responses_to_heat_exercise_and_hypohydration_ L2 - https://medlineplus.gov/exerciseandphysicalfitness.html DB - PRIME DP - Unbound Medicine ER -