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Childhood-onset restless legs syndrome.
Ann Neurol 2004; 56(6):803-7AN

Abstract

The clinical characteristics of childhood-onset restless legs syndrome are described. Thirty-two of 538 subjects (5.9%) examined in our sleep disorders center received diagnoses of restless legs syndrome. They were classified based on published criteria into probable (n = 9/32 or 28%) and definite (n = 23/32 or 78%) categories. Apart from an earlier age of diagnosis of the probable group, no differences were found between the two categories. Sleep onset or sleep maintenance insomnia was the most common symptoms, being present in 28 of 32 subjects (87.5%). Inattentiveness was seen in 8 of 32 subjects (25%). Serum ferritin levels were measured in 24 of 32 subjects and were below 50 microg/L in 20 of 24 subjects (83%). A family history of restless legs syndrome was present in 23 of 32 (72%) subjects, with mothers almost three times more likely to be affected than fathers (p = 0.02). We conclude that iron deficiency and a strong family history are characteristic of childhood-onset restless legs syndrome.

Authors+Show Affiliations

Division of Child and Adolescent Neurology, Mayo Clinic, Rochester, MN, USA. kotagal.suresh@mayo.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15505786

Citation

Kotagal, Suresh, and Michael H. Silber. "Childhood-onset Restless Legs Syndrome." Annals of Neurology, vol. 56, no. 6, 2004, pp. 803-7.
Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol. 2004;56(6):803-7.
Kotagal, S., & Silber, M. H. (2004). Childhood-onset restless legs syndrome. Annals of Neurology, 56(6), pp. 803-7.
Kotagal S, Silber MH. Childhood-onset Restless Legs Syndrome. Ann Neurol. 2004;56(6):803-7. PubMed PMID: 15505786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood-onset restless legs syndrome. AU - Kotagal,Suresh, AU - Silber,Michael H, PY - 2004/10/27/pubmed PY - 2005/1/12/medline PY - 2004/10/27/entrez SP - 803 EP - 7 JF - Annals of neurology JO - Ann. Neurol. VL - 56 IS - 6 N2 - The clinical characteristics of childhood-onset restless legs syndrome are described. Thirty-two of 538 subjects (5.9%) examined in our sleep disorders center received diagnoses of restless legs syndrome. They were classified based on published criteria into probable (n = 9/32 or 28%) and definite (n = 23/32 or 78%) categories. Apart from an earlier age of diagnosis of the probable group, no differences were found between the two categories. Sleep onset or sleep maintenance insomnia was the most common symptoms, being present in 28 of 32 subjects (87.5%). Inattentiveness was seen in 8 of 32 subjects (25%). Serum ferritin levels were measured in 24 of 32 subjects and were below 50 microg/L in 20 of 24 subjects (83%). A family history of restless legs syndrome was present in 23 of 32 (72%) subjects, with mothers almost three times more likely to be affected than fathers (p = 0.02). We conclude that iron deficiency and a strong family history are characteristic of childhood-onset restless legs syndrome. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/15505786/full_citation L2 - https://doi.org/10.1002/ana.20292 DB - PRIME DP - Unbound Medicine ER -