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Childhood-onset restless legs syndrome.

Abstract

The clinical characteristics of childhood-onset restless legs syndrome are described. Thirty-two of 538 subjects (5.9%) examined in our sleep disorders center received diagnoses of restless legs syndrome. They were classified based on published criteria into probable (n = 9/32 or 28%) and definite (n = 23/32 or 78%) categories. Apart from an earlier age of diagnosis of the probable group, no differences were found between the two categories. Sleep onset or sleep maintenance insomnia was the most common symptoms, being present in 28 of 32 subjects (87.5%). Inattentiveness was seen in 8 of 32 subjects (25%). Serum ferritin levels were measured in 24 of 32 subjects and were below 50 microg/L in 20 of 24 subjects (83%). A family history of restless legs syndrome was present in 23 of 32 (72%) subjects, with mothers almost three times more likely to be affected than fathers (p = 0.02). We conclude that iron deficiency and a strong family history are characteristic of childhood-onset restless legs syndrome.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Child and Adolescent Neurology, Mayo Clinic, Rochester, MN, USA. kotagal.suresh@mayo.edu

    Source

    Annals of neurology 56:6 2004 Dec pg 803-7

    MeSH

    Adolescent
    Age of Onset
    Anemia, Iron-Deficiency
    Chi-Square Distribution
    Child
    Child, Preschool
    Female
    Humans
    Male
    Restless Legs Syndrome
    Retrospective Studies
    Statistics, Nonparametric

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15505786

    Citation

    Kotagal, Suresh, and Michael H. Silber. "Childhood-onset Restless Legs Syndrome." Annals of Neurology, vol. 56, no. 6, 2004, pp. 803-7.
    Kotagal S, Silber MH. Childhood-onset restless legs syndrome. Ann Neurol. 2004;56(6):803-7.
    Kotagal, S., & Silber, M. H. (2004). Childhood-onset restless legs syndrome. Annals of Neurology, 56(6), pp. 803-7.
    Kotagal S, Silber MH. Childhood-onset Restless Legs Syndrome. Ann Neurol. 2004;56(6):803-7. PubMed PMID: 15505786.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Childhood-onset restless legs syndrome. AU - Kotagal,Suresh, AU - Silber,Michael H, PY - 2004/10/27/pubmed PY - 2005/1/12/medline PY - 2004/10/27/entrez SP - 803 EP - 7 JF - Annals of neurology JO - Ann. Neurol. VL - 56 IS - 6 N2 - The clinical characteristics of childhood-onset restless legs syndrome are described. Thirty-two of 538 subjects (5.9%) examined in our sleep disorders center received diagnoses of restless legs syndrome. They were classified based on published criteria into probable (n = 9/32 or 28%) and definite (n = 23/32 or 78%) categories. Apart from an earlier age of diagnosis of the probable group, no differences were found between the two categories. Sleep onset or sleep maintenance insomnia was the most common symptoms, being present in 28 of 32 subjects (87.5%). Inattentiveness was seen in 8 of 32 subjects (25%). Serum ferritin levels were measured in 24 of 32 subjects and were below 50 microg/L in 20 of 24 subjects (83%). A family history of restless legs syndrome was present in 23 of 32 (72%) subjects, with mothers almost three times more likely to be affected than fathers (p = 0.02). We conclude that iron deficiency and a strong family history are characteristic of childhood-onset restless legs syndrome. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/15505786/full_citation L2 - https://doi.org/10.1002/ana.20292 DB - PRIME DP - Unbound Medicine ER -