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The effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Eur J Ophthalmol. 2004 Sep-Oct; 14(5):394-400.EJ

Abstract

PURPOSE

To evaluate the changes of intraocular pressure (IOP) and retrobulbar hemodynamics after cyclopentolate administration in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

METHODS

Eighteen patients with pseudoexfoliation syndrome and 18 patients with pseudoexfoliation glaucoma were enrolled in the study. After baseline measurements of IOP, the peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) of the ophthalmic, central retinal, and posterior ciliary arteries were investigated by color Doppler imaging. Then, 1% cyclopentolate was instilled in one eye of each subject. After 45 minutes of instillation of the cyclopentolate, the measurements of IOP and retrobulbar blood flow velocities were repeated. The results were compared with those of 20 age-matched normal subjects.

RESULTS

Neither IOP nor retrobulbar blood flow velocities changed significantly in control subjects after cyclopentolate administration. IOP increased significantly after cyclopentolate instillation in pseudoexfoliation syndrome (p = 0.004). Retrobulbar blood velocities did not change significantly after the cyclopentolate in this group. In pseudoexfoliation glaucoma group, it was observed that basal mean IOP showed a statistically significant increase after cyclopentolate drop (p = 0.002). Although blood flow velocities of ophthalmic artery did not change significantly, PSV and EDV of the central retinal and posterior ciliary arteries decreased significantly (p < 0.05) and RI of the posterior ciliary artery increased significantly (p = 0.01) after cyclopentolate instillation.

CONCLUSIONS

On the basis of our findings, pseudoexfoliation appears to be a predictive factor for an IOP rise after cyclopentolate. In pseudoexfoliation glaucoma patients, an increase of IOP after cyclopentolate could lead to a decreased retrobulbar blood flow. IOP must be rechecked after cyclopentolate administration in these patients to avoid further damage to the ganglion cells.

Authors+Show Affiliations

Ophthalmology Department, Kirikkale University Faculty of Medicine, Kirikkale--Turkey. pelintaner@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15506601

Citation

Taner, P, et al. "The Effects of Cyclopentolate On Intraocular Pressure and Retrobulbar Hemodynamics in Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma." European Journal of Ophthalmology, vol. 14, no. 5, 2004, pp. 394-400.
Taner P, Unal B, Demirbaş E, et al. The effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Eur J Ophthalmol. 2004;14(5):394-400.
Taner, P., Unal, B., Demirbaş, E., & Ergin, A. (2004). The effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. European Journal of Ophthalmology, 14(5), 394-400.
Taner P, et al. The Effects of Cyclopentolate On Intraocular Pressure and Retrobulbar Hemodynamics in Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Eur J Ophthalmol. 2004 Sep-Oct;14(5):394-400. PubMed PMID: 15506601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of cyclopentolate on intraocular pressure and retrobulbar hemodynamics in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. AU - Taner,P, AU - Unal,B, AU - Demirbaş,E, AU - Ergin,A, PY - 2004/10/28/pubmed PY - 2004/12/16/medline PY - 2004/10/28/entrez SP - 394 EP - 400 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 14 IS - 5 N2 - PURPOSE: To evaluate the changes of intraocular pressure (IOP) and retrobulbar hemodynamics after cyclopentolate administration in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. METHODS: Eighteen patients with pseudoexfoliation syndrome and 18 patients with pseudoexfoliation glaucoma were enrolled in the study. After baseline measurements of IOP, the peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) of the ophthalmic, central retinal, and posterior ciliary arteries were investigated by color Doppler imaging. Then, 1% cyclopentolate was instilled in one eye of each subject. After 45 minutes of instillation of the cyclopentolate, the measurements of IOP and retrobulbar blood flow velocities were repeated. The results were compared with those of 20 age-matched normal subjects. RESULTS: Neither IOP nor retrobulbar blood flow velocities changed significantly in control subjects after cyclopentolate administration. IOP increased significantly after cyclopentolate instillation in pseudoexfoliation syndrome (p = 0.004). Retrobulbar blood velocities did not change significantly after the cyclopentolate in this group. In pseudoexfoliation glaucoma group, it was observed that basal mean IOP showed a statistically significant increase after cyclopentolate drop (p = 0.002). Although blood flow velocities of ophthalmic artery did not change significantly, PSV and EDV of the central retinal and posterior ciliary arteries decreased significantly (p < 0.05) and RI of the posterior ciliary artery increased significantly (p = 0.01) after cyclopentolate instillation. CONCLUSIONS: On the basis of our findings, pseudoexfoliation appears to be a predictive factor for an IOP rise after cyclopentolate. In pseudoexfoliation glaucoma patients, an increase of IOP after cyclopentolate could lead to a decreased retrobulbar blood flow. IOP must be rechecked after cyclopentolate administration in these patients to avoid further damage to the ganglion cells. SN - 1120-6721 UR - https://www.unboundmedicine.com/medline/citation/15506601/The_effects_of_cyclopentolate_on_intraocular_pressure_and_retrobulbar_hemodynamics_in_patients_with_pseudoexfoliation_syndrome_and_pseudoexfoliation_glaucoma_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=15506601.ui DB - PRIME DP - Unbound Medicine ER -