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[Study of mixed dry binders in directly compressible lactoses and microcrystalline cellulose].
Ceska Slov Farm. 2004 Sep; 53(5):264-7.CS

Abstract

The paper evaluated the compressibility of dry binders prepared in the ratios of 3:1, 1:1, and 1:3 from Pharmatosa DCL 15 and DCL 21 and Avicel PH 200, and the sensitivity of the mixtures to an addition of the lubricant magnesium stearate from the standpoint of the effect on the strength of tablets. Mixtures of lactoses with Avicel PH -200 in a ratio of 3:1 proved to be most advantageous. The strengths of tablets made of these mixtures oscillated in the optimal range and they showed the least sensitivity to the added lubricant. An increase in stearate concentration did not result in a marked decrease in the strength of compacts. Pharmatosa DCL 21 in a mixture with Avicel PH 200 yielded stronger compacts at lower compression force than Pharmatosa DCL 15.

Authors+Show Affiliations

Muzíková J
Katedra farmaceutické technologie, Farmaceutiché fakulty, Univerzity Karlovy, Hradec Králové. muzikova@faf.cuni.cz
Vinklarová S
No affiliation info available

MeSH

CelluloseCompressive StrengthLactosePharmaceutic AidsTablets

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

15506713

Citation

Muzíková, J, and S Vinklarová. "[Study of Mixed Dry Binders in Directly Compressible Lactoses and Microcrystalline Cellulose]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 53, no. 5, 2004, pp. 264-7.
Muzíková J, Vinklarová S. [Study of mixed dry binders in directly compressible lactoses and microcrystalline cellulose]. Ceska Slov Farm. 2004;53(5):264-7.
Muzíková, J., & Vinklarová, S. (2004). [Study of mixed dry binders in directly compressible lactoses and microcrystalline cellulose]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 53(5), 264-7.
Muzíková J, Vinklarová S. [Study of Mixed Dry Binders in Directly Compressible Lactoses and Microcrystalline Cellulose]. Ceska Slov Farm. 2004;53(5):264-7. PubMed PMID: 15506713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of mixed dry binders in directly compressible lactoses and microcrystalline cellulose]. AU - Muzíková,J, AU - Vinklarová,S, PY - 2004/10/28/pubmed PY - 2004/12/16/medline PY - 2004/10/28/entrez SP - 264 EP - 7 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 53 IS - 5 N2 - The paper evaluated the compressibility of dry binders prepared in the ratios of 3:1, 1:1, and 1:3 from Pharmatosa DCL 15 and DCL 21 and Avicel PH 200, and the sensitivity of the mixtures to an addition of the lubricant magnesium stearate from the standpoint of the effect on the strength of tablets. Mixtures of lactoses with Avicel PH -200 in a ratio of 3:1 proved to be most advantageous. The strengths of tablets made of these mixtures oscillated in the optimal range and they showed the least sensitivity to the added lubricant. An increase in stearate concentration did not result in a marked decrease in the strength of compacts. Pharmatosa DCL 21 in a mixture with Avicel PH 200 yielded stronger compacts at lower compression force than Pharmatosa DCL 15. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/15506713/[Study_of_mixed_dry_binders_in_directly_compressible_lactoses_and_microcrystalline_cellulose]_ DB - PRIME DP - Unbound Medicine ER -