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Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects.
J Agric Food Chem. 2004 Nov 03; 52(22):6802-9.JA

Abstract

Dietary supplements manufactured from red clover are widely marketed to provide the beneficial health effects of isoflavones without changing the original diet. In this study the metabolism of formononetin and biochanin A, the principal isoflavones of red clover, was studied in human subjects. Seven women ingested four red clover dietary supplements, and the metabolites of the isoflavones were identified in their urine samples. The structures of trimethylsilyl derivatives of the metabolites were established by GC-MS. New reduced metabolites of formononetin (dihydroformononetin and angolensin) and biochanin A (dihydrobiochanin A and 6'-hydroxyangolensin) were identified in urine samples using authentic reference compounds. Possible metabolic pathways are presented for the red clover isoflavones formononetin and biochanin A.

Authors+Show Affiliations

Folkhälsan Research Center and Department of Clinical Chemistry, University of Helsinki, Finland. Satu-Maarit.Heinonen@helsinki.fiNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15506819

Citation

Heinonen, Satu-Maarit, et al. "Identification of Urinary Metabolites of the Red Clover Isoflavones Formononetin and Biochanin a in Human Subjects." Journal of Agricultural and Food Chemistry, vol. 52, no. 22, 2004, pp. 6802-9.
Heinonen SM, Wähälä K, Adlercreutz H. Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. J Agric Food Chem. 2004;52(22):6802-9.
Heinonen, S. M., Wähälä, K., & Adlercreutz, H. (2004). Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. Journal of Agricultural and Food Chemistry, 52(22), 6802-9.
Heinonen SM, Wähälä K, Adlercreutz H. Identification of Urinary Metabolites of the Red Clover Isoflavones Formononetin and Biochanin a in Human Subjects. J Agric Food Chem. 2004 Nov 3;52(22):6802-9. PubMed PMID: 15506819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. AU - Heinonen,Satu-Maarit, AU - Wähälä,Kristiina, AU - Adlercreutz,Herman, PY - 2004/10/28/pubmed PY - 2004/12/16/medline PY - 2004/10/28/entrez SP - 6802 EP - 9 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 52 IS - 22 N2 - Dietary supplements manufactured from red clover are widely marketed to provide the beneficial health effects of isoflavones without changing the original diet. In this study the metabolism of formononetin and biochanin A, the principal isoflavones of red clover, was studied in human subjects. Seven women ingested four red clover dietary supplements, and the metabolites of the isoflavones were identified in their urine samples. The structures of trimethylsilyl derivatives of the metabolites were established by GC-MS. New reduced metabolites of formononetin (dihydroformononetin and angolensin) and biochanin A (dihydrobiochanin A and 6'-hydroxyangolensin) were identified in urine samples using authentic reference compounds. Possible metabolic pathways are presented for the red clover isoflavones formononetin and biochanin A. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15506819/Identification_of_urinary_metabolites_of_the_red_clover_isoflavones_formononetin_and_biochanin_A_in_human_subjects_ L2 - https://dx.doi.org/10.1021/jf0492767 DB - PRIME DP - Unbound Medicine ER -