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Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia.

Abstract

Two hundred and forty-five human influenza A and B viruses isolated in Australia between 1996 and 2003 were tested for their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir using a fluorescence-based neuraminidase inhibition assay. Based on mean IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. Influenza A viruses with a N1 subtype and influenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas influenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. A comparison of IC50 values for viruses isolated before and after the release of the NA inhibitors in Australia, found there was no significant difference in the sensitivity of strains to either neuraminidase inhibitor and none of the isolates tested showed clinically significant resistance.

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  • Authors+Show Affiliations

    ,

    WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia. Aeron_Hurt@csl.com.au

    , , , ,

    Source

    MeSH

    Acetamides
    Antiviral Agents
    Australia
    Drug Resistance, Viral
    Enzyme Inhibitors
    Guanidines
    Humans
    Influenza A virus
    Influenza B virus
    Influenza, Human
    Microbial Sensitivity Tests
    Neuraminidase
    Oseltamivir
    Population Surveillance
    Pyrans
    Sialic Acids
    Zanamivir

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15508516

    Citation

    Hurt, Aeron C., et al. "Surveillance for Neuraminidase Inhibitor Resistance in Human Influenza Viruses From Australia." Communicable Diseases Intelligence Quarterly Report, vol. 27, no. 4, 2003, pp. 542-7.
    Hurt AC, Barr IG, Durrant CJ, et al. Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia. Commun Dis Intell Q Rep. 2003;27(4):542-7.
    Hurt, A. C., Barr, I. G., Durrant, C. J., Shaw, R. P., Sjogren, H. M., & Hampson, A. W. (2003). Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia. Communicable Diseases Intelligence Quarterly Report, 27(4), pp. 542-7.
    Hurt AC, et al. Surveillance for Neuraminidase Inhibitor Resistance in Human Influenza Viruses From Australia. Commun Dis Intell Q Rep. 2003;27(4):542-7. PubMed PMID: 15508516.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Surveillance for neuraminidase inhibitor resistance in human influenza viruses from Australia. AU - Hurt,Aeron C, AU - Barr,Ian G, AU - Durrant,Christopher J, AU - Shaw,Robert P, AU - Sjogren,Helen M, AU - Hampson,Alan W, PY - 2004/10/29/pubmed PY - 2004/11/17/medline PY - 2004/10/29/entrez SP - 542 EP - 7 JF - Communicable diseases intelligence quarterly report JO - Commun Dis Intell Q Rep VL - 27 IS - 4 N2 - Two hundred and forty-five human influenza A and B viruses isolated in Australia between 1996 and 2003 were tested for their sensitivity to the NA inhibitor drugs, zanamivir and oseltamivir using a fluorescence-based neuraminidase inhibition assay. Based on mean IC50 values, influenza A viruses (with neuraminidase subtypes N1 and N2) were more sensitive to both the NA inhibitors than were influenza B strains. Influenza A viruses with a N1 subtype and influenza B strains both demonstrated a greater sensitivity to zanamivir than to oseltamivir carboxylate, whereas influenza A strains with a N2 subtype were more susceptible to oseltamivir carboxylate. A comparison of IC50 values for viruses isolated before and after the release of the NA inhibitors in Australia, found there was no significant difference in the sensitivity of strains to either neuraminidase inhibitor and none of the isolates tested showed clinically significant resistance. SN - 1447-4514 UR - https://www.unboundmedicine.com/medline/citation/15508516/Surveillance_for_neuraminidase_inhibitor_resistance_in_human_influenza_viruses_from_Australia_ L2 - http://www.health.gov.au/internet/main/publishing.nsf/Content/cda-pubs-cdi-2003-cdi2704-htm-cdi2704x.htm DB - PRIME DP - Unbound Medicine ER -