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Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis.
Ann Trop Med Parasitol. 2004 Oct; 98(7):715-24.AT

Abstract

Matrix metalloproteinases (MMP) have been implicated in the pathogenesis of various inflammatory diseases of the central nervous system. In the present study, a gelatinase was found to be induced in parasitic meningitis caused, in mice, by Angiostrongylus cantonensis. The enzyme had a molecular weight of about 94 kDa, showed maximal activity between pH 6 and pH 8, and was clearly inhibited by EDTA and 1,10-phenanthroline but not by leupeptin or phenylmethanesulphonyl fluoride. When samples of cerebrospinal fluid from the mice with meningitis were blotted with specific antiserum against gelatinase B (MMP-9), a 94-kDa immunopositive band was observed, indicating that the induced gelatinase was MMP-9. In the A. cantonensis-infected mice, immuno-histochemistry demonstrated MMP-9 within the endothelial cells lining the vascular spaces of the brain and in the leucocytes that were found, in aggregates, in the subarachnoid space. Leucocytes may play an important role in the pathogenesis of inflammatory disorders of the central nervous system.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15509425

Citation

Lai, S C., et al. "Induction of Matrix Metalloproteinase-9 in Murine Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis." Annals of Tropical Medicine and Parasitology, vol. 98, no. 7, 2004, pp. 715-24.
Lai SC, Twu JJ, Jiang ST, et al. Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. Ann Trop Med Parasitol. 2004;98(7):715-24.
Lai, S. C., Twu, J. J., Jiang, S. T., Hsu, J. D., Chen, K. M., Chiaing, H. C., Wang, C. J., Tseng, C. K., Shyu, L. Y., & Lee, H. H. (2004). Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. Annals of Tropical Medicine and Parasitology, 98(7), 715-24.
Lai SC, et al. Induction of Matrix Metalloproteinase-9 in Murine Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis. Ann Trop Med Parasitol. 2004;98(7):715-24. PubMed PMID: 15509425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. AU - Lai,S C, AU - Twu,J J, AU - Jiang,S T, AU - Hsu,J D, AU - Chen,K M, AU - Chiaing,H C, AU - Wang,C J, AU - Tseng,C K, AU - Shyu,L Y, AU - Lee,H H, PY - 2004/10/29/pubmed PY - 2005/3/16/medline PY - 2004/10/29/entrez SP - 715 EP - 24 JF - Annals of tropical medicine and parasitology JO - Ann Trop Med Parasitol VL - 98 IS - 7 N2 - Matrix metalloproteinases (MMP) have been implicated in the pathogenesis of various inflammatory diseases of the central nervous system. In the present study, a gelatinase was found to be induced in parasitic meningitis caused, in mice, by Angiostrongylus cantonensis. The enzyme had a molecular weight of about 94 kDa, showed maximal activity between pH 6 and pH 8, and was clearly inhibited by EDTA and 1,10-phenanthroline but not by leupeptin or phenylmethanesulphonyl fluoride. When samples of cerebrospinal fluid from the mice with meningitis were blotted with specific antiserum against gelatinase B (MMP-9), a 94-kDa immunopositive band was observed, indicating that the induced gelatinase was MMP-9. In the A. cantonensis-infected mice, immuno-histochemistry demonstrated MMP-9 within the endothelial cells lining the vascular spaces of the brain and in the leucocytes that were found, in aggregates, in the subarachnoid space. Leucocytes may play an important role in the pathogenesis of inflammatory disorders of the central nervous system. SN - 0003-4983 UR - https://www.unboundmedicine.com/medline/citation/15509425/Induction_of_matrix_metalloproteinase_9_in_murine_eosinophilic_meningitis_caused_by_Angiostrongylus_cantonensis_ L2 - https://medlineplus.gov/meningitis.html DB - PRIME DP - Unbound Medicine ER -