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Cytotoxic and antimicrobial coumarins from Mammea africana.
Ann Trop Med Parasitol. 2004 Oct; 98(7):733-9.AT

Abstract

Six coumarin derivatives [three 4-phenylcoumarins (Mammea A/AA, Mammea A/BA and MAB 3), two 4-n-propylcoumarins (Mammea B/BB and Mammea B/BA) and one 4-n-pentylcoumarin (Mammea C/OB)], 1,5-dihydroxyxanthone and 1-methoxy-5-hydroxyxanthone have been isolated from the stem bark of Mammea africana Sabine collected in Cameroon. Although known, the structures of the coumarin derivatives were confirmed by spectral analysis, including two-dimensional nuclear magnetic resonance. All the coumarin compounds showed noteworthy cytotoxicity against the human 9-KB cell line. Both of the 4-n-propylcoumarins were also found to exhibit significant activity against Staphylococcus aureus.

Authors+Show Affiliations

Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15509427

Citation

Ouahouo, B M W., et al. "Cytotoxic and Antimicrobial Coumarins From Mammea Africana." Annals of Tropical Medicine and Parasitology, vol. 98, no. 7, 2004, pp. 733-9.
Ouahouo BM, Azebaze AG, Meyer M, et al. Cytotoxic and antimicrobial coumarins from Mammea africana. Ann Trop Med Parasitol. 2004;98(7):733-9.
Ouahouo, B. M., Azebaze, A. G., Meyer, M., Bodo, B., Fomum, Z. T., & Nkengfack, A. E. (2004). Cytotoxic and antimicrobial coumarins from Mammea africana. Annals of Tropical Medicine and Parasitology, 98(7), 733-9.
Ouahouo BM, et al. Cytotoxic and Antimicrobial Coumarins From Mammea Africana. Ann Trop Med Parasitol. 2004;98(7):733-9. PubMed PMID: 15509427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic and antimicrobial coumarins from Mammea africana. AU - Ouahouo,B M W, AU - Azebaze,A G B, AU - Meyer,M, AU - Bodo,B, AU - Fomum,Z T, AU - Nkengfack,A E, PY - 2004/10/29/pubmed PY - 2005/3/16/medline PY - 2004/10/29/entrez SP - 733 EP - 9 JF - Annals of tropical medicine and parasitology JO - Ann Trop Med Parasitol VL - 98 IS - 7 N2 - Six coumarin derivatives [three 4-phenylcoumarins (Mammea A/AA, Mammea A/BA and MAB 3), two 4-n-propylcoumarins (Mammea B/BB and Mammea B/BA) and one 4-n-pentylcoumarin (Mammea C/OB)], 1,5-dihydroxyxanthone and 1-methoxy-5-hydroxyxanthone have been isolated from the stem bark of Mammea africana Sabine collected in Cameroon. Although known, the structures of the coumarin derivatives were confirmed by spectral analysis, including two-dimensional nuclear magnetic resonance. All the coumarin compounds showed noteworthy cytotoxicity against the human 9-KB cell line. Both of the 4-n-propylcoumarins were also found to exhibit significant activity against Staphylococcus aureus. SN - 0003-4983 UR - https://www.unboundmedicine.com/medline/citation/15509427/Cytotoxic_and_antimicrobial_coumarins_from_Mammea_africana_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -