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Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents.
J Antimicrob Chemother. 2004 Dec; 54(6):1134-8.JA

Abstract

OBJECTIVES

Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria.

METHODS

MICs were determined by agar dilution in Mueller-Hinton medium.

RESULTS

Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem.

CONCLUSIONS

Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections.

Authors+Show Affiliations

Centre de Recherches du Service de Santé des Armées Emile Pardé, Département de Biologie des Agents Transmissibles, F-38702 La Tronche, France. fthibault@crssa.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15509614

Citation

Thibault, F M., et al. "Antibiotic Susceptibility of 65 Isolates of Burkholderia Pseudomallei and Burkholderia Mallei to 35 Antimicrobial Agents." The Journal of Antimicrobial Chemotherapy, vol. 54, no. 6, 2004, pp. 1134-8.
Thibault FM, Hernandez E, Vidal DR, et al. Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. J Antimicrob Chemother. 2004;54(6):1134-8.
Thibault, F. M., Hernandez, E., Vidal, D. R., Girardet, M., & Cavallo, J. D. (2004). Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. The Journal of Antimicrobial Chemotherapy, 54(6), 1134-8.
Thibault FM, et al. Antibiotic Susceptibility of 65 Isolates of Burkholderia Pseudomallei and Burkholderia Mallei to 35 Antimicrobial Agents. J Antimicrob Chemother. 2004;54(6):1134-8. PubMed PMID: 15509614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. AU - Thibault,F M, AU - Hernandez,E, AU - Vidal,D R, AU - Girardet,M, AU - Cavallo,J-D, Y1 - 2004/10/27/ PY - 2004/10/29/pubmed PY - 2005/2/26/medline PY - 2004/10/29/entrez SP - 1134 EP - 8 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 54 IS - 6 N2 - OBJECTIVES: Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria. METHODS: MICs were determined by agar dilution in Mueller-Hinton medium. RESULTS: Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem. CONCLUSIONS: Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/15509614/Antibiotic_susceptibility_of_65_isolates_of_Burkholderia_pseudomallei_and_Burkholderia_mallei_to_35_antimicrobial_agents_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkh471 DB - PRIME DP - Unbound Medicine ER -