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Genetic predisposition to colorectal cancer.
Nat Rev Cancer. 2004 Oct; 4(10):769-80.NR

Abstract

High-penetrance mutations in several genes have been identified that contribute to hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well understood and their detection is successfully used in clinical diagnosis. In stark contrast, our understanding of the influence of low-penetrance mutations that account for most of the remaining familial cases of colorectal cancer, as well as an unknown proportion of sporadic cases, is far less advanced. Extensive ongoing research into low-penetrance, multifactorial predisposition to colorectal cancer is now beginning to bear fruit, with important implications for understanding disease aetiology and developing new diagnostic, preventive and therapeutic strategies.

Authors+Show Affiliations

Human Cancer Genetics Program, The Ohio State University, 646 Tzagournis Medical Research Facility, 420 W. 12th Avenue, Columbus, Ohio 43210, USA. delachapelle-1@medctr.osu.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15510158

Citation

de la Chapelle, Albert. "Genetic Predisposition to Colorectal Cancer." Nature Reviews. Cancer, vol. 4, no. 10, 2004, pp. 769-80.
de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer. 2004;4(10):769-80.
de la Chapelle, A. (2004). Genetic predisposition to colorectal cancer. Nature Reviews. Cancer, 4(10), 769-80.
de la Chapelle A. Genetic Predisposition to Colorectal Cancer. Nat Rev Cancer. 2004;4(10):769-80. PubMed PMID: 15510158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic predisposition to colorectal cancer. A1 - de la Chapelle,Albert, PY - 2004/10/29/pubmed PY - 2004/12/16/medline PY - 2004/10/29/entrez SP - 769 EP - 80 JF - Nature reviews. Cancer JO - Nat. Rev. Cancer VL - 4 IS - 10 N2 - High-penetrance mutations in several genes have been identified that contribute to hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well understood and their detection is successfully used in clinical diagnosis. In stark contrast, our understanding of the influence of low-penetrance mutations that account for most of the remaining familial cases of colorectal cancer, as well as an unknown proportion of sporadic cases, is far less advanced. Extensive ongoing research into low-penetrance, multifactorial predisposition to colorectal cancer is now beginning to bear fruit, with important implications for understanding disease aetiology and developing new diagnostic, preventive and therapeutic strategies. SN - 1474-175X UR - https://www.unboundmedicine.com/medline/citation/15510158/Genetic_predisposition_to_colorectal_cancer_ L2 - http://dx.doi.org/10.1038/nrc1453 DB - PRIME DP - Unbound Medicine ER -