Tags

Type your tag names separated by a space and hit enter

Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea.
Sleep Med 2004; 5(6):593-6SM

Abstract

BACKGROUND AND PURPOSE

Obstructive sleep apnea (OSA) is associated with intermittent hypoxia and cognitive decrements. As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity.

PATIENTS AND METHODS

Eight males with OSA and five age-matched controls underwent neurocognitive testing before and after polysomnography and proton magnetic resonance spectra were obtained from the left hippocampal area of all subjects.

RESULTS

In the left hippocampal area, N-acetyl-containing/creatine-containing compounds was significantly increased in OSA (P=0.04). Inspection of these compounds with respect to the water resonance indicated that this was most likely due to a decrease in creatine-containing compounds rather than any change in N-acetyl-containing compounds. Lower levels of hippocampal creatine-containing compounds were correlated with worse OSA severity and neurocognitive performance.

CONCLUSIONS

We suggest the changes in creatine levels in the hippocampal area represent adjustments to brain bioenergetics, similar to those seen in ischemic preconditioning, and may reflect the different susceptibility of these tissues to hypoxic damage in OSA.

Authors+Show Affiliations

Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia. delwynb@med.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15511707

Citation

Bartlett, Delwyn J., et al. "Hippocampal Area Metabolites Relate to Severity and Cognitive Function in Obstructive Sleep Apnea." Sleep Medicine, vol. 5, no. 6, 2004, pp. 593-6.
Bartlett DJ, Rae C, Thompson CH, et al. Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Med. 2004;5(6):593-6.
Bartlett, D. J., Rae, C., Thompson, C. H., Byth, K., Joffe, D. A., Enright, T., & Grunstein, R. R. (2004). Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Medicine, 5(6), pp. 593-6.
Bartlett DJ, et al. Hippocampal Area Metabolites Relate to Severity and Cognitive Function in Obstructive Sleep Apnea. Sleep Med. 2004;5(6):593-6. PubMed PMID: 15511707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. AU - Bartlett,Delwyn J, AU - Rae,Caroline, AU - Thompson,Campbell H, AU - Byth,Karen, AU - Joffe,David A, AU - Enright,Tony, AU - Grunstein,Ron R, PY - 2004/04/14/received PY - 2004/08/11/revised PY - 2004/08/15/accepted PY - 2004/10/30/pubmed PY - 2005/3/23/medline PY - 2004/10/30/entrez SP - 593 EP - 6 JF - Sleep medicine JO - Sleep Med. VL - 5 IS - 6 N2 - BACKGROUND AND PURPOSE: Obstructive sleep apnea (OSA) is associated with intermittent hypoxia and cognitive decrements. As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity. PATIENTS AND METHODS: Eight males with OSA and five age-matched controls underwent neurocognitive testing before and after polysomnography and proton magnetic resonance spectra were obtained from the left hippocampal area of all subjects. RESULTS: In the left hippocampal area, N-acetyl-containing/creatine-containing compounds was significantly increased in OSA (P=0.04). Inspection of these compounds with respect to the water resonance indicated that this was most likely due to a decrease in creatine-containing compounds rather than any change in N-acetyl-containing compounds. Lower levels of hippocampal creatine-containing compounds were correlated with worse OSA severity and neurocognitive performance. CONCLUSIONS: We suggest the changes in creatine levels in the hippocampal area represent adjustments to brain bioenergetics, similar to those seen in ischemic preconditioning, and may reflect the different susceptibility of these tissues to hypoxic damage in OSA. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/15511707/Hippocampal_area_metabolites_relate_to_severity_and_cognitive_function_in_obstructive_sleep_apnea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(04)00158-3 DB - PRIME DP - Unbound Medicine ER -