Tags

Type your tag names separated by a space and hit enter

Five-year incidence of cataract in older persons with diabetes and pre-diabetes.
Ophthalmic Epidemiol. 2004 Oct; 11(4):271-7.OE

Abstract

PURPOSE

To investigate longitudinal associations between diabetes and the 5-year incidence of cataract and cataract surgery. (A population-based, cohort study of 2335 persons with baseline ages 49 years or older resident in the Blue Mountains region, west of Sydney, Australia).

METHODS

Baseline information on diabetes history was collected during an interviewer-administered questionnaire. Impaired Fasting Glucose (IFG) was defined as venous plasma glucose between 6.0 and 7.0 mmol/L and newly diagnosed diabetes as plasma glucose >7.0 mmol/L, using fasting blood glucose measurements taken at baseline. Retroillumination lens photographs from the baseline and 5-year follow-up examinations were graded for presence of cortical, posterior subcapsular (PSC) and nuclear cataract.

RESULTS

We found a 2-fold higher 5-year incidence of cortical cataract in participants with IFG, multivariate adjusted odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1-4.1. Incident PSC cataract was more frequent among persons with diabetes, but this association was statistically significant only for those with newly diagnosed diabetes, multivariate adjusted OR 4.5 (CI 1.5-13.0). There were no statistically significant associations found between incident nuclear cataract or cataract surgery and either diabetes or IFG.

CONCLUSIONS

These epidemiological data suggest that IFG, a pre-diabetic condition, may be a risk factor for the development of cortical cataract.

Authors+Show Affiliations

University of Sydney, Department of Ophthalmology, Westmead Millennium Institute, Centre for Vision Research, Westmead Hospital, Sydney, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15512989

Citation

Saxena, Sonia, et al. "Five-year Incidence of Cataract in Older Persons With Diabetes and Pre-diabetes." Ophthalmic Epidemiology, vol. 11, no. 4, 2004, pp. 271-7.
Saxena S, Mitchell P, Rochtchina E. Five-year incidence of cataract in older persons with diabetes and pre-diabetes. Ophthalmic Epidemiol. 2004;11(4):271-7.
Saxena, S., Mitchell, P., & Rochtchina, E. (2004). Five-year incidence of cataract in older persons with diabetes and pre-diabetes. Ophthalmic Epidemiology, 11(4), 271-7.
Saxena S, Mitchell P, Rochtchina E. Five-year Incidence of Cataract in Older Persons With Diabetes and Pre-diabetes. Ophthalmic Epidemiol. 2004;11(4):271-7. PubMed PMID: 15512989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year incidence of cataract in older persons with diabetes and pre-diabetes. AU - Saxena,Sonia, AU - Mitchell,Paul, AU - Rochtchina,Elena, PY - 2004/10/30/pubmed PY - 2005/1/26/medline PY - 2004/10/30/entrez SP - 271 EP - 7 JF - Ophthalmic epidemiology JO - Ophthalmic Epidemiol VL - 11 IS - 4 N2 - PURPOSE: To investigate longitudinal associations between diabetes and the 5-year incidence of cataract and cataract surgery. (A population-based, cohort study of 2335 persons with baseline ages 49 years or older resident in the Blue Mountains region, west of Sydney, Australia). METHODS: Baseline information on diabetes history was collected during an interviewer-administered questionnaire. Impaired Fasting Glucose (IFG) was defined as venous plasma glucose between 6.0 and 7.0 mmol/L and newly diagnosed diabetes as plasma glucose >7.0 mmol/L, using fasting blood glucose measurements taken at baseline. Retroillumination lens photographs from the baseline and 5-year follow-up examinations were graded for presence of cortical, posterior subcapsular (PSC) and nuclear cataract. RESULTS: We found a 2-fold higher 5-year incidence of cortical cataract in participants with IFG, multivariate adjusted odds ratio (OR) 2.2, 95% confidence interval (CI) 1.1-4.1. Incident PSC cataract was more frequent among persons with diabetes, but this association was statistically significant only for those with newly diagnosed diabetes, multivariate adjusted OR 4.5 (CI 1.5-13.0). There were no statistically significant associations found between incident nuclear cataract or cataract surgery and either diabetes or IFG. CONCLUSIONS: These epidemiological data suggest that IFG, a pre-diabetic condition, may be a risk factor for the development of cortical cataract. SN - 0928-6586 UR - https://www.unboundmedicine.com/medline/citation/15512989/Five_year_incidence_of_cataract_in_older_persons_with_diabetes_and_pre_diabetes_ L2 - http://www.tandfonline.com/doi/full/10.1080/09286580490510733 DB - PRIME DP - Unbound Medicine ER -