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No association of the dopamine D4 receptor (DRD4) and -521 C/T promoter polymorphisms with infant attachment disorganization.
Attach Hum Dev. 2004 Sep; 6(3):211-8; discussion 219-22.AH

Abstract

In a first molecular genetic study Lakatos and colleagues found an association between attachment disorganization and the dopamine D4 receptor (DRD4) gene polymorphism, in particular in the presence of the -521 T allele in the promoter region of the DRD4 gene. Replication of their study in a sample of 132 infants did not confirm the role of the DRD4 7+ -allele and the -521C/T promoter gene in disorganized attachment. Although our sample was larger, and contained more children with CT or TT alleles, which enhanced the probability of finding the DRD4 and C/T interaction, the association was not found. Even when we combined our sample with the Lakatos sample, the interaction effect of the DRD4 and -521 C/T polymorphisms on disorganized attachment was absent.

Authors+Show Affiliations

bakermans@fsw.leidenuniv.nlNo affiliation info available

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

15513263

Citation

Bakermans-Kranenburg, M J., and M H. Van Ijzendoorn. "No Association of the Dopamine D4 Receptor (DRD4) and -521 C/T Promoter Polymorphisms With Infant Attachment Disorganization." Attachment & Human Development, vol. 6, no. 3, 2004, pp. 211-8; discussion 219-22.
Bakermans-Kranenburg MJ, Van Ijzendoorn MH. No association of the dopamine D4 receptor (DRD4) and -521 C/T promoter polymorphisms with infant attachment disorganization. Attach Hum Dev. 2004;6(3):211-8; discussion 219-22.
Bakermans-Kranenburg, M. J., & Van Ijzendoorn, M. H. (2004). No association of the dopamine D4 receptor (DRD4) and -521 C/T promoter polymorphisms with infant attachment disorganization. Attachment & Human Development, 6(3), 211-8; discussion 219-22.
Bakermans-Kranenburg MJ, Van Ijzendoorn MH. No Association of the Dopamine D4 Receptor (DRD4) and -521 C/T Promoter Polymorphisms With Infant Attachment Disorganization. Attach Hum Dev. 2004;6(3):211-8; discussion 219-22. PubMed PMID: 15513263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No association of the dopamine D4 receptor (DRD4) and -521 C/T promoter polymorphisms with infant attachment disorganization. AU - Bakermans-Kranenburg,M J, AU - Van Ijzendoorn,M H, PY - 2004/10/30/pubmed PY - 2005/3/4/medline PY - 2004/10/30/entrez SP - 211-8; discussion 219-22 JF - Attachment & human development JO - Attach Hum Dev VL - 6 IS - 3 N2 - In a first molecular genetic study Lakatos and colleagues found an association between attachment disorganization and the dopamine D4 receptor (DRD4) gene polymorphism, in particular in the presence of the -521 T allele in the promoter region of the DRD4 gene. Replication of their study in a sample of 132 infants did not confirm the role of the DRD4 7+ -allele and the -521C/T promoter gene in disorganized attachment. Although our sample was larger, and contained more children with CT or TT alleles, which enhanced the probability of finding the DRD4 and C/T interaction, the association was not found. Even when we combined our sample with the Lakatos sample, the interaction effect of the DRD4 and -521 C/T polymorphisms on disorganized attachment was absent. SN - 1461-6734 UR - https://www.unboundmedicine.com/medline/citation/15513263/No_association_of_the_dopamine_D4_receptor__DRD4__and__521_C/T_promoter_polymorphisms_with_infant_attachment_disorganization_ L2 - http://www.tandfonline.com/doi/full/10.1080/14616730412331281584 DB - PRIME DP - Unbound Medicine ER -