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Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection.
Scand J Gastroenterol. 2004 Aug; 39(8):778-82.SJ

Abstract

BACKGROUND

There is a limited amount of published data on the interference of hepatitis B virus (HBV) on hepatitis C virus (HCV). The aim of this study was to investigate the effect of concurrent HBV infection on serum titers of HCV RNA and HCV antibody profiles in chronic HCV infection.

METHODS

The clinical and virological profiles (serum titers of HCV RNA, HCV genotypes and antibody profiles) of 25 patients with chronic HBV-HCV coinfection were compared with those of 25 age- and sex-matched patients with HCV infection alone.

RESULTS

Among the 25 patients with HBV-HCV coinfection, only 3 were found hepatitis Be antigen (HBeAg) and HBV DNA positive by hybridization assays, and the other 11 were found HBV DNA positive by polymerase chain reaction. Genotype 1b was dominant in both HBV-HCV coinfection and HCV infection alone (64% versus 84%, P > 0.1). Patients with HBV-HCV coinfection had significantly lower alanine aminotransferase (ALAT) levels and inflammatory scores but higher fibrosis scores than those with HCV infection alone. Serum titers of HCV RNA were significantly lower in HBV-HCV coinfection than in HCV infection alone. The frequency and relative intensity of antibody response to core, E2/NS1, NS3, and NS5 showed no significant difference between the two groups, but antibody response to NS4 was diminished significantly in HBV-HCV coinfection.

CONCLUSIONS

In HBV-HCV coinfection, serum levels of HBV DNA are usually low or undetectable. Concurrent HBV infection, however, could interfere with HCV replication and suppress antibody response to NS4. The biological significance of selective inhibition of humoral immune response to NS4 in HBV-HCV coinfection should be further studied.

Authors+Show Affiliations

Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan. chu0066@cgmh.org.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15513365

Citation

Chu, C M., et al. "Low-level Hepatitis C Viremia and Humoral Immune Response to NS4 in Chronic Hepatitis B Virus-hepatitis C Virus Coinfection." Scandinavian Journal of Gastroenterology, vol. 39, no. 8, 2004, pp. 778-82.
Chu CM, Sheen IS, Liaw YF. Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection. Scand J Gastroenterol. 2004;39(8):778-82.
Chu, C. M., Sheen, I. S., & Liaw, Y. F. (2004). Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection. Scandinavian Journal of Gastroenterology, 39(8), 778-82.
Chu CM, Sheen IS, Liaw YF. Low-level Hepatitis C Viremia and Humoral Immune Response to NS4 in Chronic Hepatitis B Virus-hepatitis C Virus Coinfection. Scand J Gastroenterol. 2004;39(8):778-82. PubMed PMID: 15513365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection. AU - Chu,C M, AU - Sheen,I S, AU - Liaw,Y F, PY - 2004/10/30/pubmed PY - 2004/12/16/medline PY - 2004/10/30/entrez SP - 778 EP - 82 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 39 IS - 8 N2 - BACKGROUND: There is a limited amount of published data on the interference of hepatitis B virus (HBV) on hepatitis C virus (HCV). The aim of this study was to investigate the effect of concurrent HBV infection on serum titers of HCV RNA and HCV antibody profiles in chronic HCV infection. METHODS: The clinical and virological profiles (serum titers of HCV RNA, HCV genotypes and antibody profiles) of 25 patients with chronic HBV-HCV coinfection were compared with those of 25 age- and sex-matched patients with HCV infection alone. RESULTS: Among the 25 patients with HBV-HCV coinfection, only 3 were found hepatitis Be antigen (HBeAg) and HBV DNA positive by hybridization assays, and the other 11 were found HBV DNA positive by polymerase chain reaction. Genotype 1b was dominant in both HBV-HCV coinfection and HCV infection alone (64% versus 84%, P > 0.1). Patients with HBV-HCV coinfection had significantly lower alanine aminotransferase (ALAT) levels and inflammatory scores but higher fibrosis scores than those with HCV infection alone. Serum titers of HCV RNA were significantly lower in HBV-HCV coinfection than in HCV infection alone. The frequency and relative intensity of antibody response to core, E2/NS1, NS3, and NS5 showed no significant difference between the two groups, but antibody response to NS4 was diminished significantly in HBV-HCV coinfection. CONCLUSIONS: In HBV-HCV coinfection, serum levels of HBV DNA are usually low or undetectable. Concurrent HBV infection, however, could interfere with HCV replication and suppress antibody response to NS4. The biological significance of selective inhibition of humoral immune response to NS4 in HBV-HCV coinfection should be further studied. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/15513365/Low_level_hepatitis_C_viremia_and_humoral_immune_response_to_NS4_in_chronic_hepatitis_B_virus_hepatitis_C_virus_coinfection_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365520410006332 DB - PRIME DP - Unbound Medicine ER -